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A Caenorhabditis elegans wee1 homolog is expressed in a temporally and spatially restricted pattern during embryonic development

  1. Author:
    Wilson, M. A.
    Hoch, R. V.
    Ashcroft, N. R.
    Kosinski, M. E.
    Golden, A.

  2. Author Address

    Golden A NCI, Gene Regulat & Chromosome Biol Lab, ABL Basic Res Program, Frederick Canc Res & Dev Ctr POB B,Bldg 539 Frederick, MD 21702 USA NCI, Gene Regulat & Chromosome Biol Lab, ABL Basic Res Program, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Biochimica et Biophysica Acta - Gene Structure & Expression
    1. 1445
    2. 1
    3. Pages: 99-109
  4. Type of Article: Article
  1. Abstract:

    A wee1 homolog, wee-1.1, is expressed in both a temporally and spatially restricted pattern during early Caenorhabditis elegans embryogenesis, and is undetectable throughout the remainder of embryogenesis. The wee-1.1 message appears to be zygotically expressed in the somatic founder cell E of the 12-cell embryo. This expression disappears when the E blastomere divides for the first time. The wee-1.1 message then appears transiently in the nuclei of the eight great-granddaughter cells of the AB somatic founder cell, just before these cells divide in the 16-cell embryo. Following this division, the wee-1.1 mRNA is no longer detectable throughout the remainder of embryogenesis. The expression of wee-1.1 in the E blastomere and in the AB progeny appears to be restricted to nuclei in prophase and metaphase of the cell cycle. Analysis of the wee-1.1 mRNA expression pattern in maternal-effect lethal mutants suggests that this expression pattern is restricted to cells of the E and AB fates in the early embryo. This mRNA expression pattern is restricted to a 10-15-min span of embryonic development and may be regulating the timing of crucial cell divisions at this early stage of development. (C) 1999 Elsevier Science B.V. All rights reserved. [References: 50]

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