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Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort

  1. Author:
    Greenough, T. C.
    Brettler, D. B.
    Kirchhoff, F.
    Alexander, L.
    Desrosiers, R. C.
    O'Brien, S. J.
    Somasundaran, M.
    Luzuriaga, K.
    Sullivan, J. L.

  2. Author Address

    Greenough TC Univ Massachusetts, Sch Med, Program Mol Med 373 Plantat St,Suite 318 Worcester, MA 01605 USA Univ Massachusetts, Sch Med, Program Mol Med Worcester, MA 01605 USA Univ Massachusetts, New England Area Comprehens Hemophilia Ctr Worcester, MA 01605 USA Univ Erlangen Nurnberg, Inst Clin & Mol Virol D-8520 Erlangen Germany New England Reg Primate Res Ctr Southborough, MA 01772 USA NCI, Lab Genomic Divers, Frederick Canc Res & Dev Ctr Frederick, MD 21701 USA
    1. Year: 1999
  2. Journal: Journal of Infectious Diseases
    1. 180
    2. 6
    3. Pages: 1790-1802
  4. Type of Article: Article
  1. Abstract:

    Seven long-term nonprogressors (LTNPs) have been identified in a cohort of 128 human immunodeficiency virus (HIV)-1 infected individuals with hemophilia. Studies included quantitation of virus by polymerase chain reaction, characterization of primary virus isolates in vitro, analysis of lymphocyte surface markers, and measurement of virus-specific cytotoxic T lymphocytes (CTLs). Viruses of LTNPs exhibited slow growth in vivo and in vitro. LTNPs had expansion of CD8 T cells with increased expression of HLA-DR. Intermittent HIV-1-specific CTL effector activity was detected in freshly isolated peripheral blood mononuclear cells of most LTNPs. CTL precursor frequencies were higher in LTNPs than in patients with progressive disease. Virus antigen-specific lymphoproliferation was vigorous in some LTNPs. Thus, LTNPs in this cohort have maintained remarkably low virus burdens and vigorous HIV-l-specific cell-mediated immunity over a 15-year period. The presence of expanded, activated CD8 T cells with cytotoxic effector function in the peripheral blood suggests ongoing viral replication. [References: 66]

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