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A new human prostate carcinoma cell line, 22R upsilon 1

  1. Author:
    Sramkoski, R. M.
    Pretlow, T. G.
    Giaconia, J. M.
    Pretlow, T. P.
    Schwartz, S.
    Sy, M. S.
    Marengo, S. R.
    Rhim, J. S.
    Zhang, D. S.
    Jacobberger, J. W.

  2. Author Address

    Jacobberger JW Case Western Reserve Univ, Ctr Canc Res 10900 Euclid Ave Cleveland, OH 44106 USA Case Western Reserve Univ, Ctr Canc Res Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Genet Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Pathol Cleveland, OH 44106 USA Case Western Reserve Univ, Dept Urol Cleveland, OH 44106 USA NCI, Lab Biochem Physiol Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: In Vitro Cellular & Developmental Biology.Animal
    1. 35
    2. 7
    3. Pages: 403-409
  4. Type of Article: Article
  1. Abstract:

    A cell line has been derived from a human prostatic carcinoma xenograft, CWR22R. This represents one of, very few available cell lines representative of this disease. The cell line is derived from a xenograft that was serially propagated in mice after castration-induced regression and relapse of the parental, androgen-dependent CWR22 xenograft. Flow cytometric and cytogenetic analysis showed that this cell line represents one hyper DNA-diploid stem line with two clonal, evolved cytogenetic sublines. The basic karyotype is close to that of the grandparent xenograft, CWR22, and is relatively simple with 50 chromosomes. In nude mice, the line forms tumors with morphology similar to that of the xenografts, and like the parental CWR22 and CWR22R xenografts, this cell line expresses prostate specific antigen. Growth is weakly stimulated by dihydroxytestosterone and lysates are immunoreactive with androgen receptor antibody by Western blot analysis. Growth is stimulated by epidermal growth factor but is not inhibited by transforming growth factor-beta 1. [References: 37]

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