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The HIV-1 virion-associated protein Vpr is a coactivator of the human glucocorticoid receptor

  1. Author:
    Kino, T.
    Gragerov, A.
    Kopp, J. B.
    Stauber, R. H.
    Pavlakis, G. N.
    Chrousos, G. P.

  2. Author Address

    Kino T NICHHD, Dev Endocrinol Branch, Sect Pediat Endocrinol, NIH Bldg 10,Rm 10N262,10 Ctr Dr MSC 1862 Bethesda, MD 20892 USA NICHHD, Dev Endocrinol Branch, Sect Pediat Endocrinol, NIH Bethesda, MD 20892 USA NIDDKD, Metab Dis Branch, Kidney Dis Sect, NIH Bethesda, MD 20892 USA NCI, Frederick Canc Res & Dev Ctr, Human Retrovirus Sect, ABL Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Journal of Experimental Medicine
    1. 189
    2. 1
    3. Pages: 51-61
  4. Type of Article: Article
  1. Abstract:

    The HIV-1 virion-associated accessor)I protein Vpr affects both viral replication and cellular transcription, proliferation, and differentiation. We report that Vpr enhances the activity of glucocorticoids in lymphoid and muscle-derive cell Lines by interacting directly with the glucocorticoid receptor and general transcription factors, acting as a coactivator. Vpr contains the signature motif LXXLL also present in cellular nuclear receptor coactivators, such as steroid receptor coactivator 1 and p300/CREB-binding protein, which mediates their interaction with the glucocorticoid and other nuclear hormone receptors. A mutant Vpr molecule with disruption of this coactivator signature motif lost its ability to influence transcription of glucocorticoid-responsive genes and became a dominant-negative inhibitor of Vpr, possibly by retaining its general transcription factor-binding activities. The glucocorticoid coactivator activity of Vpr may contribute to increased tissue glucocorticoid sensitivity in the absence of hypercortisolism and to the pathogenesis of AIDS. [References: 56]

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