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The thrombospondin-4 gene

  1. Author:
    Newton, G.
    Weremowicz, S.
    Morton, C. C.
    Jenkins, N. A.
    Gilbert, D. J.
    Copeland, N. G.
    Lawler, J.

  2. Author Address

    Lawler J Beth Israel Deaconess Med Ctr, Dept Pathol Res N RN-270C,99 Brookline Ave Boston, MA 02215 USA Beth Israel Deaconess Med Ctr, Dept Pathol Boston, MA 02215 USA Harvard Univ, Sch Med Boston, MA 02215 USA Brigham & Womens Hosp, Dept Pathol Boston, MA 02115 USA Brigham & Womens Hosp, Dept Obstet Gynecol & Reprod Biol Boston, MA 02115 USA NCI, Mammalian Genet Lab, ABL Basic Res Program, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Mammalian Genome
    1. 10
    2. 10
    3. Pages: 1010-1016
  4. Type of Article: Article
  1. Abstract:

    Thrombospondins are a family of extracellular, adhesive proteins that are widely expressed in vertebrates. Five distinct gene products, designated thrombospondin-1 through -4 and cartilage oligomeric matrix protein (COMP), have been identified. With the exception of thrombospondin-4, the structure and location of thrombospondin genes have been determined in the human and/or mouse genomes. In this study, the structure and location of the murine thrombospondin-4 gene and the location of the human thrombospondin-4, gene are reported. The murine thrombospondin-4 gene is approximately 4.5 kb in length and includes 22 exons, Interspecific backcross analysis of progeny derived from matings of (C57BL/6J x Mus spretus)F-1 x C57BL/6J mice indicates that the thrombospondin-4 gene is tightly linked to the Dhfr locus on murine Chromosome (Chr) 13. The human gene maps to Chr 5 in band q13 by in situ hybridization to human metaphase chromosomes. The thrombospondin-4, promoter is similar to promoters of some housekeeping, growth control, and other thrombospondin genes in that it contains multiple GC box sequences and lacks a CAAT box. The presence of multiple E-box sequence motifs is consistent with thrombospondin-4 expression in muscle and bone tissue. [References: 65]

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