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Quantitative proviral DNA and antibody levels in the natural history of HTLV-I infection

  1. Author:
    Manns, A.
    Miley, W. J.
    Wilks, R. J.
    Morgan, O. S. C.
    Hanchard, B.
    Wharfe, G.
    Cranston, B.
    Maloney, E.
    Welles, S. L.
    Blattner, W. A.
    Waters, D.

  2. Author Address

    Manns A 6120 Execut Blvd,Rm 8008 Rockville, MD 20852 USA NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet Bethesda, MD 20892 USA NCI, Frederick Canc Res & Dev Ctr, SAIC Frederick, MD USA Univ Maryland, Inst Human Virol Baltimore, MD 21201 USA Univ Minnesota, Div Epidemiol Minneapolis, MN 55455 USA Univ W Indies, Trop Metab Res Unit, Dept Hematol Kingston 7 Jamaica Univ W Indies, Dept Med Kingston 7 Jamaica Univ W Indies, Dept Pathol Kingston 7 Jamaica
    1. Year: 1999
  2. Journal: Journal of Infectious Diseases
    1. 180
    2. 5
    3. Pages: 1487-1493
  4. Type of Article: Article
  1. Abstract:

    The pathogenesis of human T-cell lymphotropic virus type I (HTLV-I) in adult T-cell leukemia/lymphoma (ATL) and HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is poorly understood. We prospectively followed up and evaluated the virologic correlates of infection in transfusion recipients after seroconversion, in asymptomatic carriers, and in ATL and HAM/TSP patients. Proviral DNA levels (copies/10(5) lymphocytes) were determined by real-time automated polymerase chain reaction and antibody titers by endpoint dilution by use of an HTLV-I enzyme-linked immunoassay, In early infection, proviral load was initially elevated (median, 212 copies/10(5) lymphocytes at time 1) and later decreased (median, 99 copies at time 2, and 27 copies at time 3), Corresponding antibody titers were low at time 1 (1 :2154), had significantly increased by time 2 (1 : 12312), and were stable by time 3 (1 :4694), These viral markers were significantly lower in asymptomatic carriers than in HAM/TSP or ATL patients. Therefore, proviral load and antibody titers may be useful as predictive markers of disease among carriers. [References: 36]

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