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Mechanisms for induction of acquired host immunity by neutrophil peptide defensins

  1. Author:
    Lillard, J. W.
    Boyaka, P. N.
    Chertov, O.
    Oppenheim, J. J.
    McGhee, J. R.

  2. Author Address

    McGhee JR Univ Alabama, Dept Microbiol 273A BBRB,845 19th St S Birmingham, AL 35294 USA Univ Alabama, Dept Microbiol Birmingham, AL 35294 USA NCI, Intramural Res Support Program, Sci Applicat Int Corp, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA NCI, Mol Immunoregulat Lab, Frederick Canc Res & Dev Ctr Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 96
    2. 2
    3. Pages: 651-656
  4. Type of Article: Article
  1. Abstract:

    Human neutrophil peptide (HNP) defensins were studied to determine their potential effects on adaptive mucosal immunity. Intranasal delivery of HNPs plus ovalbumin (OVA) enhanced OVA-specific serum IgG antibody (Ab) responses. However, OVA-specific IgA Abs were not induced in mucosal secretions or in serum. CD4(+) T cells of intranasally immunized mice displayed higher OVA-specific proliferative responses and elevated production of interferon gamma, interleukin (IL) 5, IL-6, and IL-10 when compared with control groups receiving OVA alone. In vitro, HNPs also enhanced both proliferative responses and T helper (Th) cytokine secretion profiles of CD3 epsilon-stimulated spleen- and Peyer's patch-derived naive CD4(+) T cells. HNPs modulated the expression of costimulatory molecules by lipopolysaccharide- or CD3 epsilon-stimulated splenic and Peyer's patch B or T cell populations, respectively. These studies show that defensins enhance systemic IgG, but not IgA, Ab responses through help provided by CD4(+) Th1- and Th2-type cytokines and foster B and T cell interactions to link innate immunity with the adaptive immune system. [References: 43]

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