Skip NavigationSkip to Content
Return Return to Search Results

Regulation and control of nitric oxide (NO) in macrophages: Protecting the "professional killer cell" from its own cytotoxic arsenal via MRP1 and GSTP1

  1. Author:
    Kovacevic, Z.
    Sahni, S.
    Lok, H.
    Davies, M. J.
    Wink, David
    Richardson, D. R.

  2. Author Address

    Univ Sydney, Dept Pathol, Mol Pharmacol & Pathol Program, Sydney, NSW 2006, Australia.Univ Copenhagen, Dept Biomed Sci, Panum Inst, Bldg 12-6,Blegdamsvej 3, DK-2200 Copenhagen, Denmark.NCI, Canc Inflammat Program, NIH, Frederick, MD 21701 USA.
    1. Year: 2017
    2. Date: May
  2. Journal: BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
  3. ELSEVIER SCIENCE BV,
    1. 1861
    2. 5 Pt A
    3. Pages: 995-999
  5. Type of Article: Review
  6. ISSN: 0304-4165
  1. Abstract:

    We recently demonstrated that a novel storage and transport mechanism for nitric oxide (NO) mediated by glutathione-S-transferase P1 (GSTP1) and multidrug resistance protein 1 (MRP1/ABCC1), protects M1-macrophage (M1-Mempty set) models from large quantities of endogenous NO. This system stores and transports NO as dinitrosyl-dithiol-iron complexes (DNICs) composed of iron, NO and glutathione (GSH). Hence, this gas with contrasting anti- and pro-tumor effects, which has been assumed to be freely diffusible, is a tightly regulated species in M1-Mempty sets. These control systems prevent NO cytotoxicity and may be responsible for delivering cytotoxic NO as DNICs via MRP1 from M1-Mempty sets, to tumor cell targets. (C) 2017 Elsevier B.V. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bbagen.2017.02.021
  3. PMID: 28219722
  4. View record in Web of Science®
  5. WOS: 000403733500004

Library Notes

  1. Fiscal Year: FY2016-2017
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel