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Genome-Wide Association Study of MKI67 Expression and its Clinical Implications in HBV-Related Hepatocellular Carcinoma in Southern China

  1. Author:
    Yang, Cheng-Kun
    Yu, Ting-Dong
    Han, Chuang-Ye
    Qin, Wei
    Liao, Xi-Wen
    Yu, Long
    Liu, Xiao-Guang
    Zhu, Guang-Zhi
    Su, Hao
    Lu, Si-Cong
    Chen, Zhi-Wei
    Liu, Zhen
    Huang, Ke-Tuan
    Liu, Zheng-Tao
    Liang, Yu
    Huang, Jian-Lu
    Mo, Zeng-Nan
    Qin, Xue
    Li, Lequn
    Xiao, Kai-Yin
    Peng, Min-Hao
    Winkler, Cheryl
    O'Brien, Stephen J
    Peng, Tao

  2. Author Address

    Department of Hepatobiliary Surgery, Nanning, China., Department of Hepatobiliary and Pancreatic Surgery, The first Affiliated Hospital of Zhengzhou University, Zhengzhou, China., Department of Hepatobiliary Surgery, Affiliated Hospital of Guangdong Medical University, Zhanjiang, China., Department of Hepatobiliary Surgery, Third Affiliated Hospital of Guangxi Medical University, Nanning, China., Center for Genomic and Personalized Medicine, Guangxi Medical University, Nanning, China., Department of Clinical Labaoratory, The first Affiliated Hospital of Guangxi Medical University, Nanning, China., Department of Hepatobiliary Surgery, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, China., Laboratory of Genomic Diversity, National Cancer Institute, Frederick, Maryland, USA.,
    1. Year: 2017
    2. Date: Jul 13
    3. Epub Date: 2017 Jul 13
  2. Journal: Cellular Physiology and Biochemistry: International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology
    1. 42
    2. 4
    3. Pages: 1342-1357
  4. Type of Article: Article
  5. Article Number: 1342-1357
  6. ISSN: 1015-8987
  1. Abstract:

    Hepatocellular carcinoma (HCC) is a common malignant tumor with a high rate of recurrence. Immunohistochemical analysis of the marker of proliferation Ki-67 (MKI67) is used to assess proliferation activity of HCC The regulation of MKI67 expression remains unclear in HCC This study aims to explore the association between MKI67 expression and gene variants. A total of 195 hepatitis B virus (HBV)-related HCC patients were genotyped using Illumina HumanExome BeadChip-12-1_A (242,901 markers). An independent cohort (97 subjects) validated the association of polymorphism determinants and candidate genes with MKI67 expression. The relationships between MKI67 with p53 and variants of candidate genes in the clinical outcomes of HCC patients were analyzed. We found that MKI67 combined with p53 was associated with a 3-year recurrence-free survival and five variants near TTN and CCDC8 were associated with MKI67 expression. TTN harboring rs2288563-TT and rs2562832-AA+CA indicated a favorable outcome for HCC patients. Variants near TTN and CCDC8 were associated with MKI67 expression, and rs2288563 and rs2562832 in TTN are potential biomarkers for the prediction of clinical outcomes in HBV-related HCC patients. © 2017 The Author(s). Published by S. Karger AG, Basel.

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External Sources

  1. View Full Text
  2. DOI: 10.1159/000478963
  3. PMID: 28700999
  4. View record in Web of Science®
  5. WOS: 000412247700007

Library Notes

  1. Fiscal Year: FY2016-2017
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