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Intracellular Reassociation of RNA-DNA Hybrids that Activates RNAi in HIV-Infected Cells.

  1. Author:
    Martins, Angelica N
    Ke, Weina
    Jawahar, Vaishnavi
    Striplin, Morriah
    Striplin, Caryn
    Freed, Eric
    Afonin, Kirill A

  2. Author Address

    Department of Biological Sciences, University of North Carolina at Charlotte, 9201 University City Boulevard, Charlotte, NC, 28223, USA., Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, 9201 University Blvd., Charlotte, NC, 28223, USA., HIV Dynamics and Replication Program, NCI, Frederick, MD, 21702, USA., Nanoscale Science Program, Department of Chemistry, University of North Carolina at Charlotte, 9201 University Blvd., Charlotte, NC, 28223, USA. kafonin@uncc.edu., The Center for Biomedical Engineering and Science, University of North Carolina at Charlotte, Charlotte, NC, 28223, USA. kafonin@uncc.edu., Center for Cancer Research, National Cancer Institute, Frederick, Maryland, 21702, USA. kafonin@uncc.edu.,
    1. Year: 2017
  2. Journal: Methods in molecular biology (Clifton, N.J.)
    1. 1632
    2. Pages: 269-283
  4. Type of Article: Article
  1. Abstract:

    Human immunodeficiency virus Type 1 (HIV-1) is the major cause of acquired immune deficiency syndrome (AIDS). In 2014, it was estimated that 1.2 million people died from AIDS-related illnesses. RNA interference-based therapy to block HIV replication is a field that, as of now, is without any FDA-approved drugs available for clinical use. In this chapter we describe a protocol for testing and utilizing a new approach that relies on reassociation of RNA-DNA hybrids activating RNAi and blocking HIV replication in human cells.

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  2. DOI: 10.1007/978-1-4939-7138-1_18
  3. PMID: 28730446

Library Notes

  1. Fiscal Year: FY2016-2017
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