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Anti-Inflammatory Effects of OxPAPC Involve Endothelial Cell-Mediated Generation of LXA4

  1. Author:
    Ke, Yunbo
    Zebda, Noureddine
    Oskolkova, Olga
    Afonyushkin, Taras
    Berdyshev, Evgeny
    Tian, Yufeng
    Meng, Fanyong
    Sarich, Nicolene
    Bochkov, Valery N.
    Wang, Jiming
    Birukova, Anna A.
    Birukov, Konstantin G.

  2. Author Address

    Univ Chicago, Dept Med, Lung Injury Ctr, Sect Pulm & Crit Med, Chicago, IL 60637 USA.Natl Jewish Hlth, Denver, CO USA.NCI, Frederick, MD 21701 USA.Karl Franzens Univ Graz, Inst Pharmaceut Sci, Graz, Austria.
    1. Year: 2017
    2. Date: Jul 21
  2. Journal: Circulation Research
  3. LIPPINCOTT WILLIAMS & WILKINS,
    1. 121
    2. 3
    3. Pages: 244-257
  5. Type of Article: Article
  6. ISSN: 0009-7330
  1. Abstract:

    Rationale: Oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphorylcholine (OxPAPC) generates a group of bioactive oxidized phospholipid products with a broad range of biological activities. Barrier-enhancing and anti-inflammatory effects of OxPAPC on pulmonary endothelial cells are critical for prevention of acute lung injury caused by bacterial pathogens or excessive mechanical ventilation. Anti-inflammatory properties of OxPAPC are associated with its antagonistic effects on Toll-like receptors and suppression of RhoA GTPase signaling.

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External Sources

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  2. DOI: 10.1161/CIRCRESAHA.116.310308
  3. PMID: 28522438
  4. View record in Web of Science®
  5. WOS: 000405893400011

Library Notes

  1. Fiscal Year: FY2016-2017
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