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Alarmins and immunity

  1. Inventor:
    Yang, De
    Han, Zhen
    Oppenheim, Joost [ORCID]

  2. Inventor Address

    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, National Institutes of Health, Frederick, MD, USA.,
    1. Year: 2017
    2. Date: Nov
  2. Published Source: Immunological Reviews
    1. 280
    2. 1
    3. Pages: 41-56
  4. Patent Type: Review
  1. Abstract:

    More than a decade has passed since the conceptualization of the "alarmin" hypothesis. The alarmin family has been expanding in terms of both number and the concept. It has recently become clear that alarmins play important roles as initiators and participants in a diverse range of physiological and pathophysiological processes such as host defense, regulation of gene expression, cellular homeostasis, wound healing, inflammation, allergy, autoimmunity, and oncogenesis. Here, we provide a general view on the participation of alarmins in the induction of innate and adaptive immune responses, as well as their contribution to tumor immunity. Published 2017. This article is a U.S. Government work and is in the public domain in the USA.

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External Sources

  1. View Full Text
  2. DOI: 10.1111/imr.12577
  3. PMID: 29027222

Library Notes

  1. Fiscal Year: FY2017-2018
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