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Detection of Bacterial Contamination in Nanoparticle Formulations by Agar Plate Test

  1. Author:
    Potter, Tim
    Neun, Barry
    Ilinskaya, Anna N
    Dobrovolskaia, Marina

  2. Author Address

    Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA., Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA. marina@mail.nih.gov.,
    1. Year: 2018
  2. Journal: Methods in molecular biology (Clifton, N.J.)
    1. 1682
    2. Pages: 19-22
  4. Type of Article: Article
  1. Abstract:

    Bacterial contamination can confound the results of in vitro and in vivo preclinical tests. This protocol describes a procedure for detection of microbial contamination in nanotechnology-based formulations. Nanoparticle samples and controls are spread on the surface of agar and growth of bacterial colonies is monitored after 72 160;h of incubation. The intended purpose of this assay is to avoid introduction of microbial contamination into in vitro cell cultures and in vivo animal studies utilizing the test nanomaterial. This assay is not intended to certify the material as sterile.

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External Sources

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  2. DOI: 10.1007/978-1-4939-7352-1_2
  3. PMID: 29039089

Library Notes

  1. Fiscal Year: FY2017-2018
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