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Elemental Analysis in Biological Matrices Using ICP-MS

  1. Author:
    Hansen, Matthew N
    Clogston, Jeffrey

  2. Author Address

    Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA., Cancer Research Technology Program, Nanotechnology Characterization Laboratory, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, P.O. Box B, Frederick, MD, 21702, USA. Jeffrey.Clogston@fnlcr.nih.gov.,
    1. Year: 2018
  2. Journal: Methods in molecular biology (Clifton, N.J.)
    1. 1682
    2. Pages: 37-47
  4. Type of Article: Article
  1. Abstract:

    The increasing exploration of metallic nanoparticles for use as cancer therapeutic agents necessitates a sensitive technique to track the clearance and distribution of the material once introduced into a living system. Inductively coupled plasma mass spectrometry (ICP-MS) provides a sensitive and selective tool for tracking the distribution of metal components from these nanotherapeutics. This chapter presents a standardized method for processing biological matrices, ensuring complete homogenization of tissues, and outlines the preparation of appropriate standards and controls. The method described herein utilized gold nanoparticle-treated samples; however, the method can easily be applied to the analysis of other metals.

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External Sources

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  2. DOI: 10.1007/978-1-4939-7352-1_4
  3. PMID: 29039091

Library Notes

  1. Fiscal Year: FY2017-2018
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