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High-mobility group nucleosome binding domain 1 (HMGN1) functions as a Th1-polarizing alarmin

  1. Inventor:
    Yang, De
    Han, Zhen
    Alam, Md Masud
    Oppenheim, Joost

  2. Inventor Address

    Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, National Institute of Health, USA. Electronic address: yangd@mail.nih.gov., Cancer and Inflammation Program, Center for Cancer Research, National Cancer Institute at Frederick, National Institute of Health, USA. Electronic address: oppenheij@mail.nih.gov.,
    1. Year: 2018
    2. Date: Mar 01
    3. International Patent Classification: 2018 03 01
  2. Published Source: Seminars in immunology
    1. Pages: pii: S1044-5323(17)30075-1
  4. Patent Type: Review
  1. Abstract:

    High-mobility group (HMG) nucleosome binding domain 1 (HMGN1), which previously was thought to function only as a nucleosome-binding protein that regulates chromatin structure, histone modifications, and gene expression, was recently discovered to be an alarmin that contributes extracellularly to the generation of innate and adaptive immune responses. HMGN1 promotes DC recruitment through interacting with a Gai protein-coupled receptor (GiPCR) and activates DCs predominantly through triggering TLR4. HMGN1 preferentially promotes Th1-type immunity, which makes it relevant for the fields of vaccinology, autoimmunity, and oncoimmunology. Here, we discuss the alarmin properties of HMGN1 and update recent advances on its roles in immunity and potential applications for immunotherapy of tumors. Copyright © 2018. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.smim.2018.02.012
  3. PMID: 29503123
  4. PII : S1044-5323(17)30075-1

Library Notes

  1. Fiscal Year: FY2017-2018
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