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Association ofTNFRSF1BPromoter Polymorphisms with Human Disease: Further Studies Examining T-Regulatory Cells Are Required

  1. Author:
    Li, Hongchuan
    Anderson, Steve

  2. Author Address

    Basic Science Program, Leidos Biomedical Research Inc., Frederick National Laboratory for Cancer Research, Frederick, MD, United States.,
    1. Year: 2018
    2. Date: Mar 6
    3. Epub Date: 2018 03 06
  2. Journal: Frontiers in immunology
    1. 9
    2. Pages: 443
  4. Type of Article: Article
  5. Article Number: 443
  6. ISSN: 1664-3224
  1. Abstract:

    The TNFR2 receptor is expressed by highly active regulatory T cells, and thus constitutes an important therapeutic target for the treatment of autoimmune disease and cancer. Disease susceptibility as well as the potential response to therapies directed at TNFR2 could be significantly impacted by genetic variation in the promoter of theTNFRSF1Bgene that codes for the TNFR2 protein. To date, only a few studies have examined the association ofTNFRSF1Bpromoter variation with disease, and the potential impact on T-regulatory cell (Treg) number and function has not been examined. We propose that copy number variation of a key transcription factor binding site has a significant effect onTNFRSF1Bpromoter activity, and should be considered in studies of disease susceptibility and especially with regard to variation in the level of TNFR2 expression on Tregs.

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External Sources

  1. View Full Text
  2. DOI: 10.3389/fimmu.2018.00443
  3. PMID: 29559979
  4. PMCID: PMC5845690
  5. View record in Web of Science®
  6. WOS: 000426729100001

Library Notes

  1. Fiscal Year: FY2017-2018
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