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The Intersection of HPV Epidemiology, Genomics and Mechanistic Studies of HPV-Mediated Carcinogenesis

  1. Author:
    Mirabello, Lisa
    Clarke, Megan A.
    Nelson, Chase W.
    Dean, Michael
    Wentzensen, Nicolas
    Yeager, Meredith
    Cullen, Michael
    Boland, Joseph
    Schiffman, Mark
    Burk, Robert D.

  2. Author Address

    NCI, DCEG, NIH, Rockville, MD 20850 USA.Sackler Inst Comparat Genom, Amer Museum Nat Hist, New York, NY 10024 USA.Leidos Biomed Res Inc, Canc Genom Res Lab, Frederick, MD 21701 USA.DCEG, NCI HPV Workshop, Rockville, MD 20850 USA.Albert Einstein Coll Med, Dept Pediat, Bronx, NY 10461 USA.Albert Einstein Coll Med, Dept Microbiol & Immunol, Bronx, NY 10461 USA.Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10461 USA.Albert Einstein Coll Med, Dept Obstet & Gynecol, Bronx, NY 10461 USA.Albert Einstein Coll Med, Dept Womens Hlth, Bronx, NY 10461 USA.
    1. Year: 2018
    2. Date: Feb 13
  2. Journal: VIRUSES-BASEL
  3. MDPI,
    1. 10
    2. 2
  5. Type of Article: Article
  6. Article Number: 80
  7. ISSN: 1999-4915
  1. Abstract:

    Of the similar to 60 human papillomavirus (HPV) genotypes that infect the cervicovaginal epithelium, only 12-13 high-risk types are well-established as causing cervical cancer, with HPV16 accounting for over half of all cases worldwide. While HPV16 is the most important carcinogenic type, variants of HPV16 can differ in their carcinogenicity by 10-fold or more in epidemiologic studies. Strong genotype-phenotype associations embedded in the small 8-kb HPV16 genome motivate molecular studies to understand the underlying molecular mechanisms. Understanding the mechanisms of HPV genomic findings is complicated by the linkage of HPV genome variants. A panel of experts in various disciplines gathered on 21 November 2016 to discuss the interdisciplinary science of HPV oncogenesis. Here, we summarize the discussion of the complexity of the viral-host interaction and highlight important next steps for selected applied basic laboratory studies guided by epidemiological genomic findings.

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External Sources

  1. View Full Text
  2. DOI: 10.3390/v10020080
  3. PMID: 29438321
  4. View record in Web of Science®
  5. WOS: 000427544100030

Library Notes

  1. Fiscal Year: FY2017-2018
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