The Association of Circulating Inflammation Proteins and Gallstone Disease

Author:

Liu, Zhiwei

Kemp, Troy

Gao, Yu-Tang

Corbel, Amanda

McGee, Emma E

Wang, Bingsheng

Shen, Ming-Chang

Rashid, Asif

Hsing, Ann W

Hildesheim, Allan

Pfeiffer, Ruth M

Pinto, Ligia

Koshiol, Jill
Author Address

Infections and Immunoepidemiology Branch of the Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland,, USA., HPV Immunology Laboratory, Frederick National Laboratory for Cancer Research, Leidos, Biomedical Research, Inc, Frederick, MD,, USA., Department of Epidemiology, Shanghai Cancer Institute, Shanghai, China., Department of General Surgery, Zhongshan Hospital, School of Medicine, Fudan University, Shanghai, China., Department of Pathology, Shanghai Cancer Center, Fudan University, Shanghai, China., Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA., Stanford Cancer Institute, Palo Alto, CA, USA., Stanford Prevention Research Center, Department of Medicine, Stanford School of Medicine, Palo Alto, CA, USA., Biostatistics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, MD, USA.,

Abstract:

Inflammation plays a role in the development of both gallstones and gallbladder cancer; however, few studies have investigated the association of circulating inflammation proteins with risk of gallstones. We measured 13 cytokines (including 10 interleukins), that have been associated with cancer in serum samples collected from 150 gallstone patients and 149 population-based controls from Shanghai, China, in 1997-2001. We estimated the associations of each cytokine, categorized into quartiles and coded as a trend, with risk of gallstones using logistic regression models adjusted for potential confounders. Higher levels of interleukin (IL)-6, IL-10, IL-12 (p70), and IL-13 were associated with increased risk of gallstones (i.e., Ptrend < 0.003, Bonferroni corrected), with odds ratios (ORs) that ranged from OR highest quartile [Q4] vs lowest quartile [Q1] = 3.2 (95% confidence interval [CI]: 1.4, 7.5) for IL-13 to OR Q4 vs. Q1 = 5.7 (95% CI: 2.5, 13.5) for IL-12 (p70). In a regression model including all four interleukins, only IL-12 retained statistical significance (P < 0.05). We found four circulating interleukins that were associated with gallstones. Future studies are needed to validate the findings and evaluate the common pathway or mechanism in the development of gallbladder diseases associated with these cytokine signatures. This article is protected by copyright. All rights reserved.

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