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Accumulation of follicular CD8+ T cells in pathogenic SIV infection

  1. Author:
    Ferrando-Martinez, Sara
    Moysi, Eirini
    Pegu, Amarendra
    Andrews, Sarah
    Nganou Makamdop, Krystelle
    Ambrozak, David
    McDermott, Adrian B
    Palesch, David
    Paiardini, Mirko
    Pavlakis, George
    Brenchley, Jason M
    Douek, Daniel
    Mascola, John R
    Petrovas, Constantinos
    Koup, Richard A

  2. Author Address

    Immunology Laboratory., Virology Laboratory., Vaccine Immunogenicity Program, and., Human Immunology Section, Vaccine Research Center (VRC), National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, Maryland, USA., Department of Pathology, Emory University School of Medicine and Yerkes National Primate Research Center, Atlanta, Georgia, USA., Human Retrovirus Section, Center for Cancer Research, National Cancer Institute (NCI), Frederick, Maryland, USA., Barrier Immunity Section, Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, Maryland, USA.,
    1. Year: 2018
    2. Date: May 01
    3. Epub Date: 2018 04 16
  2. Journal: The Journal of Clinical Investigation
    1. 128
    2. 5
    3. Pages: 2089-2103
  4. Type of Article: Article
  1. Abstract:

    LN follicles constitute major reservoir sites for HIV/SIV persistence. Cure strategies could benefit from the characterization of CD8+ T cells able to access and eliminate HIV-infected cells from these areas. In this study, we provide a comprehensive analysis of the phenotype, frequency, localization, and functionality of follicular CD8+ T cells (fCD8+) in SIV-infected nonhuman primates. Although disorganization of follicles was a major factor, significant accumulation of fCD8+ cells during chronic SIV infection was also observed in intact follicles, but only in pathogenic SIV infection. In line with this, tissue inflammatory mediators were strongly associated with the accumulation of fCD8+ cells, pointing to tissue inflammation as a major factor in this process. These fCD8+ cells have cytolytic potential and can be redirected to target and kill HIV-infected cells using bispecific antibodies. Altogether, our data support the use of SIV infection to better understand the dynamics of fCD8+ cells and to develop bispecific antibodies as a strategy for virus eradication.

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External Sources

  1. View Full Text
  2. DOI: 10.1172/JCI96207
  3. PMID: 29664020
  4. View record in Web of Science®
  5. WOS: 000431959100034
  6. PII : 96207

Library Notes

  1. Fiscal Year: FY2017-2018
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