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KRAS Activating Signaling Triggers Arteriovenous Malformations

  1. Author:
    Cheng, Feixiong
    Nussinov, Ruth

  2. Author Address

    Center for Complex Networks Research and Department of Physics, Northeastern University, Boston, MA 02115, USA; Center for Cancer Systems Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA. Electronic address: fxcheng1985@gmail.com., Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, MD 21702, USA; Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel. Electronic address: nussinor@mail.nih.gov.,
    1. Year: 2018
    2. Date: Jul
    3. Epub Date: 2018 05 07
  2. Journal: Trends in Biochemical Sciences
    1. 43
    2. 7
    3. Pages: 481-483
  4. Type of Article: Letter
  1. Abstract:

    The underlying genetic causes and altered signaling pathways of brain arteriovenous malformations remain unknown. A study published in The New England Journal of Medicine reported that KRAS somatic mutations (p.Gly12Val/Asp) were identified in brain arteriovenous malformations of human subjects and endothelial cell-enriched cultures, which might specifically activate the MAPK (mitogen-activated protein kinase)-ERK (extracellular signal-regulated kinase) signaling pathway in brain endothelial cells. Copyright © 2018 Elsevier Ltd. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.tibs.2018.04.007
  3. PMID: 29748115
  4. PMCID: PMC6014919
  5. View record in Web of Science®
  6. WOS: 000436452200001
  7. PII : S0968-0004(18)30082-3

Library Notes

  1. Fiscal Year: FY2017-2018
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