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Cytotoxic and other withanolides from aeroponically grown Physalis philadelphica

  1. Author:
    Xu, Ya-Ming
    Wijeratne, E M Kithsiri
    Brooks, Alan
    Tewary, Poonam
    Xuan, Li-Jiang
    Wang, Wen-Qiong
    Sayers, Thomas
    Gunatilaka, A A Leslie

  2. Author Address

    Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706, United States., Basic Research Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute-Frederick, Maryland 21702, United States; Cancer and Inflammation Program, National Cancer Institute-Frederick, Maryland 21702, United States., State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 501 Haike Road, Zhangjiang Hi-Tech Park, Shanghai 201203, PR China., Natural Products Center, School of Natural Resources and the Environment, College of Agriculture and Life Sciences, The University of Arizona, 250 E. Valencia Road, Tucson, AZ 85706, United States. Electronic address: leslieg1@email.arizona.edu.,
    1. Year: 2018
    2. Date: Aug
    3. Epub Date: 2018 05 15
  2. Journal: Phytochemistry
    1. 152
    2. Pages: 174-181
  4. Type of Article: Article
  5. ISSN: 0031-9422
  1. Abstract:

    Eleven withanolides including six previously undescribed compounds, 16ß-hydroxyixocarpanolide, 24,25-dihydroexodeconolide C, 16,17-dehydro-24-epi-dioscorolide A, 17-epi-philadelphicalactone A, 16-deoxyphiladelphicalactone C, and 4-deoxyixocarpalactone A were isolated from aeroponically grown Physalis philadelphica. Structures of these withanolides were elucidated by the analysis of their spectroscopic (HRMS, 1D and 2D NMR, ECD) data and comparison with published data for related withanolides. Cytotoxic activity of all isolated compounds was evaluated against a panel of five human tumor cell lines (LNCaP, ACHN, UO-31, M14 and SK-MEL-28), and normal (HFF) cells. Of these, 17-epi-philadelphicalactone A, withaphysacarpin, philadelphicalactone C, and ixocarpalactone A exhibited cytotoxicity against ACHN, UO-31, M14 and SK-MEL-28, but showed no toxicity to HFF cells. Copyright © 2018 Elsevier Ltd. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.phytochem.2018.04.018
  3. PMID: 29775868
  4. View record in Web of Science®
  5. WOS: 000437383300020
  6. PII : S0031-9422(18)30117-1

Library Notes

  1. Fiscal Year: FY2017-2018
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