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Identification of a novel Sry-related gene and its germ cell-specific expression

  1. Author:
    Osaki, E.
    Nishina, Y.
    Inazawa, J.
    Copeland, N. G.
    Gilbert, D. J.
    Jenkins, N. A.
    Ohsugi, M.
    Tezuka, T.
    Yoshida, M.
    Semba, K.

  2. Author Address

    Semba K Univ Tokyo, Inst Med Sci, Dept Cell & Mol Biol, Minato Ku 4-6-1 Shirokanedai Tokyo 1088639 Japan Univ Tokyo, Inst Med Sci, Dept Cell & Mol Biol, Minato Ku Tokyo 1088639 Japan Univ Tokyo, Inst Med Sci, Dept Oncol, Minato Ku Tokyo 1088639 Japan Yokohama City Univ, Grad Sch Integrated Sci, Dept Biol, Kanazawa Ku Yokohama Kanagawa 2360027 Japan Yokohama City Univ, Fac Sci, Kanazawa Ku Yokohama Kanagawa 2360027 Japan Tokyo Med & Dent Univ, Inst Med Res, Div Genet, Dept Mol Cytogenet,Bunkyo Ku Tokyo 1138519 Japan NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program, Mammalian Genet Lab Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Nucleic Acids Research
    1. 27
    2. 12
    3. Pages: 2503-2510
  4. Type of Article: Article
  1. Abstract:

    Sox family proteins are characterized by a unique DNA-binding domain, a HMG box which shows at least 50% sequence similarity with mouse Sry, the sex-determining factor. At present almost 30 Sox genes have been identified, Members of this family have been shown to be conserved during evolution and to play key roles during animal development. Some are involved in human diseases, including sex reversal. Here we report the isolation of a novel member of the Sox gene family, Sox30, which may constitute a distinct subgroup of this family, Using a bacterially expressed DNA-binding domain of Sox30, we show that it is able to specifically recognize the ACAAT motif. Furthermore, Sox30 is capable of activating transcription from a synthetic promoter containing the ACAAT motif. The specific expression of Sox30 in normal testes, but not in maturing germ cell-deficient testes, suggests the involvement of Sox30 in differentiation of male germ cells. Mapping analyses revealed that the Sox30 gene is located on human chromosome 5 (5q33) and on mouse chromosome 11. [References: 51]

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