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Translational Repression By a Transcriptional Elongation Factor

  1. Author:
    Wilson, H. R.
    Kameyama, L.
    Zhou, J. G.
    Guarneros, G.
    Court, D. L.

  2. Author Address

    Court DL NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM MOL CONTROL & GENET SECT FREDERICK, MD 21702 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM MOL CONTROL & GENET SECT FREDERICK, MD 21702 USA INST POLITECN NACL CTR INVEST & ESTUDIOS AVANZADOS DEPT GENET & MOL BIOL MEXICO CITY 14 DF MEXICO
    1. Year: 1997
  2. Journal: Genes & Development
    1. 11
    2. 17
    3. Pages: 2204-2213
  4. Type of Article: Article
  1. Abstract:

    One of the classical positive regulators of gene expression is bacteriophage lambda N protein. N regulates the transcription of early phage genes by participating in the formation of a highly pro ces sive, terminator-resistant transcription complex and thereby stimulates the expression of genes lying downstream of transcriptional terminators. Also included in this antiterminating transcription complex are an RNA site (NUT) and host proteins (Nus). Here we demonstrate that N has an additional, hitherto unknown regulatory role, as a repressor of the translation of its own gene. N-dependent repression does not occur when NUT is deleted, demonstrating that N-mediated antitermination and translational repression both require the same cis-acting site in the RNA. In addition, we have identified one nut and several host mutations that eliminate antitermination and not translational repression, suggesting the independence of these two N-mediated mechanisms. finally, the position of nutL with respect to the gene whose expression is repressed is important. [References: 77]

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