Skip NavigationSkip to Content
Return Return to Search Results

Patterns of Sensitivity to a Panel of Drugs are highly Individualized for Undifferentiated/Unclassified Soft Tissue Sarcoma (USTS) in Patient-Derived Orthotopic Xenograft (PDOX) Nude-Mouse Models

  1. Author:
    Kawaguchi, Kei
    Igarashi, Kentaro
    Miyake, Kentaro
    Kiyuna, Tasuku
    Miyake, Masuyo
    Singh, Arun S
    Chmielowski, Bartosz
    Nelson, Scott D
    Russell, Tara A
    Dry, Sarah M
    Li, Yunfeng
    Unno, Michiaki
    Singh, Shree Ram
    Eilber, Fritz C
    Hoffman, Robert M

  2. Author Address

    a AntiCancer, Inc. , San Diego , CA., b Department of Surgery , University of California , San Diego , CA., c Department of Surgery , Graduate School of Medicine, Tohoku University , Sendai , Japan., d Division of Hematology-Oncology , University of California , Los Angeles , CA., e Department of Pathology , University of California , Los Angeles , CA., f Division of Surgical Oncology , University of California , Los Angeles , CA., g Basic Research Laboratory , National Cancer Institute , Frederick , MD.,
    1. Year: 2018
    2. Date: Jul 19
    3. Epub Date: 2018 07 19
  2. Journal: Journal of drug targeting
    1. Pages: 1-25
  4. Type of Article: Article
  1. Abstract:

    Undifferentiated/unclassified soft tissue sarcoma (USTS) is a recalcitrant disease, therefore, precise individualized therapy is needed. Toward this goal, we previously established patient-derived orthotopic xenograft (PDOX) models of USTS in nude mice. Here, we determined the extent of uniqueness of drug response in a panel on USTS PDOX models from 5 different patients. We previously showed that 3 of the 5 patients were resistant to DOX despite DOX being first-line therapy. Two weeks after orthotopic tumor implantation, PDOX mouse models were randomized into five groups: untreated control, doxorubicin (DOX), gemcitabine/docetaxel (GEM/DOC), pazopanib (PAZ); temozolomide (TEM) and 3 PDOX cases completely resistant to DOX. TEM had high efficacy for 4 USTS PDOX models, including DOX-resistant cases. GEM/DOC and PAZ were effective in three USTS PDOX. One case was completely resistance to TEM. Two cases were completely resistant to PAZ. The results showed the drug sensitivity pattern for each USTS PDOX was highly individualized and that at least one effective drug could be found for each. The PDOX model could be effective in precise individualized drug sensitivity testing which is especially important for heterogeneous cancers such as USTS, and can give the patient a greater chance to be treated with an effective drug.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1080/1061186X.2018.1499748
  3. PMID: 30024282

Library Notes

  1. Fiscal Year: FY2017-2018
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel