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Growth of HPV-18 immortalized human prostatic intraepithelial neoplasia cell lines. Influence of IL-10, follistatin, activin-A, and DHT

  1. Author:
    Wang, M.
    Liu, A.
    Garcia, F. U.
    Rhim, J. S.
    Stearns, M. E.

  2. Author Address

    Stearns ME MCP Hahnemann Univ, Dept Pathol & Lab Med Broad & Vine St Philadelphia, PA 19102 USA MCP Hahnemann Univ, Dept Pathol & Lab Med Philadelphia, PA 19102 USA NCI, NIH Frederick, MD 21701 USA
    1. Year: 1999
  2. Journal: International Journal of Oncology
    1. 14
    2. 6
    3. Pages: 1185-1195
  4. Type of Article: Article
  1. Abstract:

    Cultures from high grade prostatic intraepithelial neoplasia (HGPIN) have been established and immortalized by HPV-18 infection. The cultures were identified as PIN by Western blotting with anti-cytokeratin (34 beta E12) and prostate specific antigen (PSA) antibodies. We examined the growth capabilities of the cultures in the presence of TGF-beta 1, activin-A, follistatin (FS), androgens (DHEA, DHT) and several cytokines (IL-10, IL-2, IL-4). IL-10, FS, and DHT stimulated cell proliferation and colony forming ability, while the other cytokines and growth factors had no discernable effect. In addition, DHT and to a lesser extent IL-10 both stimulated PSA production. Activin-A blocked IL-10, FS, and DHT stimulated growth and PSA production. We interpret the data to mean that IL-IO induction of FS secretion (and FS binding of activin A) restores the normal growth capabilities of HGPIN cultures. [References: 46]

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