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Keeping up with the prostate-specific membrane antigens (PSMAs): an introduction to a new class of positron emission tomography (PET) imaging agents

  1. Author:
    Czarniecki, Marcin
    Mena, Esther
    Lindenberg, Liza
    Cacko, Marek
    Harmon, Stephanie
    Radtke, Jan Philipp
    Giesel, Frederick
    Turkbey, Baris
    Choyke, Peter L.

  2. Author Address

    NCI, Mol Imaging Program, NIH, Bethesda, MD 20892 USA.Med Univ Warsaw, Dept Nucl Med, Warsaw, Poland.NCI, Clin Res Directorate, Clin Monitoring Res Program, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.Heidelberg Univ Hosp, Dept Urol, INF 400, D-69120 Heidelberg, Germany.Heidelberg Univ Hosp, Dept Nucl Med, INF 400, D-69120 Heidelberg, Germany.
    1. Year: 2018
    2. Date: Oct
  2. Journal: Translational andrology and urology
  3. AME PUBL CO,
    1. 7
    2. 5
    3. Pages: 831-843
  5. Type of Article: Review
  6. ISSN: 2223-4683
  1. Abstract:

    Prostate-specific membrane antigen (PSMA) targeted positron emission tomography (PET) is an emerging prostate cancer imaging method, which has been reported to have a higher sensitivity and specificity than the currently approved PET imaging agents. Multiple PSMA ligands are being investigated around the world and applications range from primary tumor characterization, to local staging, biochemical recurrence, metastasis, and image-guided interventions. The most investigated PET tracers are labelled with 68-Gallium or 18-Fluoride and are discussed in this review. Additionally, Tc-99m labeled PSMA agents for single photon emission computed tomography (SPECT) imaging are elucidated as an alternative method of PSMA image acquisition.

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External Sources

  1. View Full Text
  2. DOI: 10.21037/tau.2018.08.03
  3. PMID: 30456186
  4. PMCID: PMC6212618
  5. View record in Web of Science®
  6. WOS: 000447937100008

Library Notes

  1. Fiscal Year: FY2018-2019
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