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Partial Rescue of Ocular Pigment Cells and Structure by Inducible Ectopic Expression of Mitf-M in MITF-Deficient Mice

  1. Author:
    Michael, Helen T.
    Graff-Cherry, Cari
    Chin, Sung
    Rauck, Corinne
    Habtemichael, Amelework D.
    Bunda, Patricia
    Smith, Tunde
    Campos, Maria M.
    Bharti, Kapil
    Arnheiter, Heinz
    Merlino, Glenn
    Day, Chi-Ping

  2. Author Address

    NCI, Lab Canc Biol & Genet, NIH, Bethesda, MD 20892 USA.NIH, Lab Anim Sci Program, Natl Frederick Lab Canc Res, Frederick, MD USA.NEI, Histopathol Core Facil, NIH, Bethesda, MD 20892 USA.NEI, Unit Ocular & Stem Cell Translat Res, NIH, Bethesda, MD 20892 USA.NINDS, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA.
    1. Year: 2018
    2. Date: Dec
  2. Journal: Investigative ophthalmology & visual science
  3. ASSOC RESEARCH VISION OPHTHALMOLOGY INC,
    1. 59
    2. 15
    3. Pages: 6067-6073
  5. Type of Article: Article
  6. ISSN: 0146-0404
  1. Abstract:

    PURPOSE. Complete deficiency of microphthalmia transcription factor (MITF) in Mitf mi-vga9/mi-vga9 mice is associated with microphthalmia, retinal dysplasia, and albinism. We investigated the ability of dopachrome tautomerase (DCT) promoter-mediated inducible ectopic expression of Mitf-M to rescue these phenotypic abnormalities.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1167/iovs.18-25186
  3. PMID: 30590377
  4. PMCID: PMC6314104
  5. View record in Web of Science®
  6. WOS: 000454713000001

Library Notes

  1. Fiscal Year: FY2018-2019
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