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Vaccine protection against SIVmac239 acquisition

  1. Author:
    Martins, Mauricio A
    Bischof, Georg F
    Shin, Young C
    Lauer, William A
    Gonzalez-Nieto, Lucas
    Watkins, David I
    Rakasz, Eva G
    Lifson, Jeffrey
    Desrosiers, Ronald C

  2. Author Address

    Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136., Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715., AIDS and Cancer Virus Program, Frederick National Laboratory for Cancer Research, Frederick, MD 21701., Department of Pathology, Miller School of Medicine, University of Miami, Miami, FL 33136; r.desrosiers@med.miami.edu.,
    1. Year: 2019
    2. Date: Jan 29
    3. Epub Date: 2019 01 14
  2. Journal: Proceedings of the National Academy of Sciences of the United States of America
    1. 116
    2. 5
    3. Pages: 1739-1744
  4. Type of Article: Article
  5. ISSN: 0027-8424
  1. Abstract:

    The biological characteristics of HIV pose serious difficulties for the success of a preventive vaccine. Molecularly cloned SIVmac239 is difficult for antibodies to neutralize, and a variety of vaccine approaches have had great difficulty achieving protective immunity against it in rhesus monkey models. Here we report significant protection against i.v. acquisition of SIVmac239 using a long-lasting approach to vaccination. The vaccine regimen includes a replication-competent herpesvirus engineered to contain a near-full-length SIV genome that expresses all nine SIV gene products, assembles noninfectious SIV virion particles, and is capable of eliciting long-lasting effector-memory cellular immune responses to all nine SIV gene products. Vaccinated monkeys were significantly protected against acquisition of SIVmac239 following repeated marginal dose i.v. challenges over a 4-month period. Further work is needed to define the critical components necessary for eliciting this protective immunity, evaluate the breadth of the protection against a variety of strains, and explore how this approach may be extended to human use.

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External Sources

  1. View Full Text
  2. DOI: 10.1073/pnas.1814584116
  3. PMID: 30642966
  4. View record in Web of Science®
  5. WOS: 000456944600045
  6. PII : 1814584116

Library Notes

  1. Fiscal Year: FY2018-2019
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