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Genotoxicity of amorphous silica nanoparticles: Status and prospects

  1. Author:
    Yazdimamaghani, Mostafa
    Moos, Philip J.
    Dobrovolskaia, Marina
    Ghandehari, Hamidreza

  2. Author Address

    Univ Utah, Dept Pharmaceut & Pharmaceut Chem, Salt Lake City, UT USA.Univ Utah, Utah Ctr Nanomed, Nano Inst Utah, Salt Lake City, UT USA.Univ Utah, Dept Pharmacol & Toxicol, 112 Skaggs Hall, Salt Lake City, UT 84112 USA.NCI, Nanotechnol Characterizat Lab, Canc Res Technol Program, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.Univ Utah, Dept Bioengn, Salt Lake City, UT 84112 USA.
    1. Year: 2019
    2. Date: Feb
    3. Epub Date: 2018 12 07
  2. Journal: Nanomedicine : nanotechnology, biology, and medicine
  3. ELSEVIER SCIENCE BV,
    1. 16
    2. Pages: 106-125
  5. Type of Article: Review
  6. ISSN: 1549-9634
  1. Abstract:

    Amorphous silica nanoparticles (SNPs) are widely used in biomedical applications and consumer products. Little is known, however, about their genotoxicity and potential to induce gene expression regulation. Despite recent efforts to study the underlying mechanisms of genotoxicity of SNPs, inconsistent results create a challenge. A variety of factors determine particle-cell interactions and underlying mechanisms. Further, high-throughput studies are required to carefully assess the impact of silica nanoparticle physicochemical properties on induction of genotoxic response in different cell lines and animal models. In this article, we review the strategies available for evaluation of genotoxicity of nanoparticles (NPs), survey current status of silica nanoparticle gene alteration and genotoxicity, discuss particle-mediated inflammation as a contributing factor to genotoxicity, identify existing gaps and suggest future directions for this research. (C) 2018 Elsevier Inc. All rights reserved.

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External Sources

  1. View Full Text
  2. DOI: 10.1016/j.nano.2018.11.013
  3. PMID: 30529789
  4. View record in Web of Science®
  5. WOS: 000460167000011

Library Notes

  1. Fiscal Year: FY2018-2019
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