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Targeting Non-coding RNA Sensitizes Cancer Cells to Drugs

  1. Author:
    Yang,Mo
    Schneekloth,Jay

  2. Author Address

    Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA., Chemical Biology Laboratory, National Cancer Institute, Frederick, MD 21702, USA. Electronic address: schneeklothjs@mail.nih.gov.,
    1. Year: 2019
    2. Date: May 20
    3. Epub Date: 2019 05 20
  2. Journal: Trends in pharmacological sciences
    1. Pages: pii: S0165-6147(19)30094-X
  4. Type of Article: Article
  1. Abstract:

    Recently, Costales and colleagues (J. Am. Chem. Soc. 2019;141:2960-2974) reported a bivalent small molecule inhibitor of primary miRNA (pri-miR)-515. Perturbation of pri-miR-515 results in the upregulation of HER2 protein levels, rendering HER2- breast cancer cells more sensitive to Herceptin treatment. This strategy represents a novel pharmacological approach to selectively modulating disease-relevant proteins in tumor cells. Copyright © 2019. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.tips.2019.04.017
  3. PMID: 31122764
  4. PII : S0165-6147(19)30094-X

Library Notes

  1. Fiscal Year: FY2018-2019
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