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The Metabolic Basis of Kidney Cancer

  1. Author:
    Linehan, W. Marston
    Schmidt,Laura
    Crooks, Daniel R.
    Wei, Darmood
    Srinivasan, Ramaprasad
    Lang, Martin
    Ricketts, Christopher J.

  2. Author Address

    NCI, Urol Oncol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA.Frederick Lab Canc Res, Basic Sci Program, Frederick, MD USA.
    1. Year: 2019
    2. Date: AUG
    3. Epub Date: 2019 05 14
  2. Journal: Cancer discovery
  3. AMER ASSOC CANCER RESEARCH,
    1. 9
    2. 8
    3. Pages: 1006-1021
  5. Type of Article: Review
  6. ISSN: 2159-8274
  1. Abstract:

    Kidney cancer is not a single disease but represents several distinct types of cancer that have defining histologies and genetic alterations and that follow different clinical courses and have different responses to therapy. Mutation of genes associated with kidney cancer, such as VHL, FLCN, TFE3, FH, or SDHB, dysregulates the tumor's responses to changes in oxygen, iron, nutrient, or energy levels. The identification of these varying genetic bases of kidney cancer has increased our understanding of the biology of this cancer, allowing the development of targeted therapies and the appreciation that it is a cancer driven by metabolic alterations. Significance: Kidney cancer is a complex disease composed of different types of cancer that present with different histologies, clinical courses, genetic changes, and responses to therapy. This review describes the known genetic changes within kidney cancer, how they alter tumor metabolism, and how these metabolic changes can be therapeutically targeted.

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External Sources

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  2. DOI: 10.1158/2159-8290.CD-18-1354
  3. PMID: 31088840
  4. View record in Web of Science®
  5. WOS: 000478015000005

Library Notes

  1. Fiscal Year: FY2018-2019
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