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A comparison of prostate cancer bone metastases on 18F-Sodium Fluoride and Prostate Specific Membrane Antigen (18F-PSMA) PET/CT: Discordant uptake in the same lesion

  1. Author:
    Harmon,Stephanie
    Mena, Esther
    Shih, Joanna H
    Adler,Stephen
    McKinney, Yolanda
    Bergvall, Ethan
    Mehralivand, Sherif
    Sowalsky, Adam G
    Couvillon, Anna
    Madan, Ravi A
    Gulley, James L
    Eary, Janet
    Mease, Ronnie C
    Pomper, Martin G
    Dahut, William L
    Turkbey, Baris
    Lindenberg, Liza
    Choyke, Peter L

  2. Author Address

    Clinical Research Directorate, Frederick National Laboratory for Cancer Research sponsored by the National Cancer Institute, Frederick, MD, USA., Molecular Imaging Program, National Cancer Institute, NIH, Bethesda, MD, USA., Biometric Research Branch, National Cancer Institute, NIH, Bethesda, MD, USA., Laboratory of Genitourinary Cancer Pathogenesis, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, MD, USA., Genitourinary Malignancies Branch, National Cancer Institute, NIH, Bethesda, MD, USA., Cancer Imaging Program, National Cancer Institute, NIH, Rockville, MD, USA., Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, USA.,
    1. Year: 2018
    2. Date: Dec 28
    3. Epub Date: 2018 12 28
  2. Journal: Oncotarget
    1. 9
    2. 102
    3. Pages: 37676-37688
  4. Type of Article: Article
  1. Abstract:

    Prostate-Specific Membrane Antigen (PSMA) PET/CT has been introduced as a sensitive method for characterizing metastatic prostate cancer. The purpose of this study is to compare the spatial concordance of 18F-NaF PET/CT and 18F-PSMA-targeted PET/CT within prostate cancer bone metastases. Prostate cancer patients with known bone metastases underwent PSMA-targeted PET/CT (18F-DCFBC or 18F-DCFPyL) and 18F-NaF PET/CT. In pelvic and spinal lesions detected by both radiotracers, regions-of-interest (ROIs) derived by various thresholds of uptake intensity were compared for spatial colocalization. Overlap volume was correlated with uptake characteristics and disease status. The study included 149 lesions in 19 patients. Qualitatively, lesions exhibited a heterogeneous range of spatial concordance between PSMA and NaF uptake from completely matched to completely discordant. Quantitatively, overlap volume decreased as a function of tracer intensity. and disease status, where lesions from patients with castration-sensitive disease showed higher spatial concordance while lesions from patients with castration-resistant disease demonstrated more frequent spatial discordance. As metastatic prostate cancer progresses from castration-sensitive to castration-resistant, greater discordance is observed between NaF PET and PSMA PET uptake. This may indicate a possible phenotypic shift to tumor growth that is more independent of bone remodeling via osteoblastic formation.

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External Sources

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  2. DOI: 10.18632/oncotarget.26481
  3. PMID: 30701023
  4. PMCID: PMC6340866
  5. PII : 26481

Library Notes

  1. Fiscal Year: FY2018-2019
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