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Roadmap and strategy for overcoming infusion reactions to nanomedicines

  1. Author:
    Szebeni, Janos
    Simberg, Dmitri
    Gonzalez-Fernandez, Africa
    Barenholz, Yechezkel
    Dobrovolskaia,Marina

  2. Author Address

    Semmelweis Univ, Nanomed Res & Educ Ctr, Inst Pathophysiol, Budapest, Hungary.SeroScience Ltd, Budapest, Hungary.Univ Miskolc, Fac Hlth, Dept Nanobiotechnol & Regenerat Med, Miskolc, Hungary.Univ Colorado, Translat Bionanosci Lab, Skaggs Sch Pharm & Pharmaceut Sci, Aurora, CO USA.Univ Vigo, Ctr Invest Biomed CINBIO, Ctr Invest Singular Galicia, Immunol,IIS GS, Vigo, Spain.Hebrew Univ Jerusalem, Inst Med Res Israel Canada, Dept Biochem, Hadassah Med Sch, Jerusalem, Israel.NCI, Nanotechnol Characterizat Lab, Canc Res Technol Program, Frederick Natl Lab Canc Res, Frederick, MD 21701 USA.
    1. Year: 2018
    2. Date: Dec
    3. Epub Date: 2018 10 22
  2. Journal: Nature nanotechnology
  3. NATURE PUBLISHING GROUP,
    1. 13
    2. 12
    3. Pages: 1100-1108
  5. Type of Article: Review
  6. ISSN: 1748-3387
  1. Abstract:

    Infusion reactions (IRs) are complex, immune-mediated side effects that mainly occur within minutes to hours of receiving a therapeutic dose of intravenously administered pharmaceutical products. These products are diverse and include both traditional pharmaceuticals (for example biological agents and small molecules) and new ones (for example nanotechnology-based products). Although IRs are not unique to nanomedicines, they represent a hurdle for the translation of nanotechnology-based drug products. This Perspective offers a big picture of the pharmaceutical field and examines current understanding of mechanisms responsible for IRs to nanomedicines. We outline outstanding questions, review currently available experimental evidence to provide some answers and highlight the gaps. We review advantages and limitations of the in vitro tests and animal models used for studying IRs to nanomedicines. Finally, we propose a roadmap to improve current understanding, and we recommend a strategy for overcoming the problem.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1038/s41565-018-0273-1
  3. PMID: 30348955
  4. PMCID: PMC6320688
  5. View record in Web of Science®
  6. WOS: 000452408300012

Library Notes

  1. Fiscal Year: FY2018-2019
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