Single Cell Sequencing of the Pineal Gland: The Next Chapter

Author:

Coon, Steven L.

Fu, Cong

Hartley, Steven W.

Holtzclaw, Lynne

Mays, Joseph C.

Kelly,Michael

Kelley, Matthew W.

Mullikin, James C.

Rath, Martin F.

Savastano, Luis E.

Klein, David C.
Author Address

Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Mol Genom Core, Off Sci Director, NIH, Bethesda, MD USA.Jilin Univ, Hosp 1, Minist Educ, Key Lab Organ Regenerat & Transplantat, Changchun, Jilin, Peoples R China.Natl Local Joint Engn Lab Anim Models Human Dis, Changchun, Jilin, Peoples R China.NHGRI, Comparat Genom Anal Unit, Canc Genet & Comparat Genom Branch, NIH, Bethesda, MD 20892 USA.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Microscopy & Imaging Core, Off Sci Director, Intramural Res Program,NIH, Bethesda, MD USA.NYU, Sch Med, Inst Syst Genet, New York, NY USA.NCI, Single Cell Anal Facil, Frederick Natl Lab Canc Res, NIH, Bethesda, MD 20892 USA.Natl Inst Deafness & Other Commun Disorders, Sect Dev Neurosci, Lab Cochlear Dev, Div Intramural Res,NIH, Bethesda, MD USA.NHGRI, Natl Inst Hlth Intramural Sequencing Ctr, NIH, Rockville, MD USA.Univ Copenhagen, Panum Inst, Dept Neurosci, Copenhagen, Denmark.Univ Michigan, Dept Neurosurg, Ann Arbor, MI 48109 USA.Eunice Kennedy Shriver Natl Inst Child Hlth & Hum, Intramural Res Program, NIH, Bethesda, MD 20892 USA.

Abstract:

The analysis of pineal cell biology has undergone remarkable development as techniques have become available which allow for sequencing of entire transcriptomes and, most recently, the sequencing of the transcriptome of individual cells. Identification of at least nine distinct cell types in the rat pineal gland has been made possible, allowing identification of the precise cells of origin and expression of transcripts for the first time. Here the history and current state of knowledge generated by these transcriptomic efforts is reviewed, with emphasis on the insights suggested by the findings.

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