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Dynamic Protein Allosteric Regulation and Disease

  1. Author:
    Nussinov,Ruth
    Tsai,Chung-Jung
    Jang,Hyunbum

  2. Author Address

    Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, MD, USA. NussinoR@mail.nih.gov., Sackler Institute of Molecular Medicine, Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel. NussinoR@mail.nih.gov.,
    1. Year: 2019
  2. Journal: Advances in experimental medicine and biology
    1. 1163
    2. Pages: 25-43
  4. Type of Article: Article
  5. ISSN: 978-981-13-8718-0
  1. Abstract:

    Allostery is largely associated with conformational and functional transitions in individual proteins. All dynamic proteins are allosteric. This concept can be extended to consider the impact of conformational perturbations on cellular function and disease states. In this section, we will illuminate how allostery can control physiological activities and cause disease, aiming to increase the awareness of the linkage between disease symptoms on the cellular level and specific aberrant allosteric actions on the molecular level. [Book Title: PROTEIN ALLOSTERY IN DRUG DISCOVERY]

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  1. Keywords:

External Sources

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  2. DOI: 10.1007/978-981-13-8719-7_2
  3. PMID: 31707698
  4. View record in Web of Science®
  5. WOS: 000514080400003

Library Notes

  1. Fiscal Year: FY2019-2020
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