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S-(4-methoxyphenyl)-4-methoxybenzenesulfonothioate as a promising lead compound for the development a renal carcinoma agent

  1. Author:
    Namtes, Camila I
    Pereira, Ingrid D
    Bai,Ruoli
    Hamel,Ernest
    Burnett,Jim
    de Oliveira, Rodrigo J
    Matos, Maria de F C
    Beatriz, Adilson
    Yonekawa, Murilo K A
    Perdomo, Renata T
    de Lima, Dênis P
    Bogo, Danielle
    Dos Santos, Edson Dos Anjos

  2. Author Address

    Universidade Federal de Mato Grosso do Sul, FACFAN, BRAZIL., Universidade Federal de Mato Grosso do Sul, INQUI, BRAZIL., NCI at Frederick, Division of Cancer Treatment and Diagnosis, UNITED STATES., NCI at Frederick, Division Cancer Treatment and Diagnosis, UNITED STATES., NCI at Frederick, Computacional Drug Development Goup, UNITED STATES., Universidade Federal de Mato Grosso do Sul, Faculdade de Medicina, BRAZIL., Universidade Federal de Mato Grosso do Sul, INBIO, BRAZIL., Universidade Federal de Mato Grosso do Sul, Instituto de Bioci 234;ncias, Avenida Costa e Silva, s/n, Laborat 243;rio de Bioqu 237;mica Geral e de Microrganismos, 79070900, Campo Grande, BRAZIL.,
    1. Year: 2020
    2. Date: JAN 16
    3. Epub Date: 2019 12 13
  2. Journal: ChemMedChem
  4. Type of Article: Article
  5. ISSN: 1860-7179
  1. Abstract:

    Organosulfur compounds show cytotoxic potential towards many tumor cell lines. Disulfides and thiosulfonates act through apoptotic processes, inducing proteins associated with apoptosis, endoplasmic reticulum stress, and the unfolded protein response. Three p -substituted symmetric diaryl disulfides and three diaryl thiosulfonates were synthesized and analyzed for inhibition of tubulin polymerization and for human cancer cell cytotoxic activity against seven tumor cell lines and a non-tumor cell line. S -(4-methoxyphenyl)-4-methoxybenzenesulfonothioate ( 6 ) exhibited inhibition of tubulin polymerization and showed the best antiproliferative potential, especially against the 786-0 cell line, being six times more selective as compared with the non-tumor cell line. In addition, compound 6 was able to activate caspase-3 after 24 and 48 h treatments of the 786-0 cell line and induced cell cycle arrest in the G2/M stage at the highest concentration evaluated at 24 and 48 h. Compound 6 was able to cause complete inhibition of proliferation, inducing the death of 786-0 cells, by increasing the number of cells at G2/M and greater activation of caspase-3. © 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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External Sources

  1. View Full Text
  2. DOI: 10.1002/cmdc.201900566
  3. PMID: 31834975
  4. View record in Web of Science®
  5. WOS: 000507436200001

Library Notes

  1. Fiscal Year: FY2019-2020
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