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Cardiovascular Biomarker Profile on Antiretroviral Therapy Is Not Influenced by History of an IRIS Event in People With HIV and Suppressed Viremia

  1. Author:
    Gouel-Cheron, Aurelie
    Nason, Martha
    Rupert,Adam
    Sheikh, Virginia
    Robby, Greg
    Fahle, Gary A
    Sereti, Irini [ORCID]

  2. Author Address

    Biostatistics Research Branch, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA., D 233;partement d 39;Anesth 233;sie et R 233;animation Chirurgicale, Universit 233; de Paris, Groupe Hospitalier Bichat Claude Bernard, Assistance Publique H 244;pitaux de Paris, Paris, France., Unit of Antibodies in Therapy and Pathology, Pasteur Institut, UMR INSERM, Paris, France., Leidos Biomedical Research Inc., NCI Campus at Frederick, Frederick, Maryland, USA., Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA., Department of Laboratory Medicine, Clinical Center (CC), National Institutes of Health, Bethesda, Maryland, USA.,
    1. Year: 2020
    2. Date: Jan
    3. Epub Date: 2020 01 11
  2. Journal: Open forum infectious diseases
    1. 7
    2. 1
    3. Pages: pii: ofaa017
  4. Type of Article: Article
  5. Article Number: ofaa017
  6. ISSN: 2328-8957
  1. Abstract:

    Immune reconstitution inflammatory syndrome (IRIS) is characterized by release of proinflammatory cytokines and tissue inflammation occurring early after antiretroviral therapy (ART) initiation. The role of previous IRIS events in persistent chronic inflammation in people with HIV is currently unclear. In this retrospective analysis of 143 participants who maintained suppression of HIV viremia, we compared biomarkers related to inflammation, coagulation, and cardiovascular risk after 3 years on ART in participants with and without a history of IRIS. There was no evidence of higher levels of persistent chronic inflammation in people with HIV who had a history of an IRIS event. ClinicalTrials.gov Identifier . NCT00286767. Published by Oxford University Press on behalf of Infectious Diseases Society of America 2020.

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External Sources

  1. View Full Text
  2. DOI: 10.1093/ofid/ofaa017
  3. PMID: 32016127
  4. PMCID: PMC6991617
  5. View record in Web of Science®
  6. WOS: 000522860700012
  7. PII : ofaa017

Library Notes

  1. Fiscal Year: FY2019-2020
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