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Anthrax toxins

  1. Author:
    Duesbery, N. S.
    Vande Woude, G. F.

  2. Author Address

    Vande Woude GF NCI, Frederick Canc Res & Dev Ctr, Div Basic Sci POB B Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, Div Basic Sci Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Cellular and Molecular Life Sciences
    1. 55
    2. 12
    3. Pages: 1599-1609
  4. Type of Article: Review
  1. Abstract:

    Though its lethal effects were ascribed to an exotoxin almost half a century ago, the pathogenesis of anthrax has yet to be satisfactorily explained. Subsequent work has led to the molecular identification and enzymatic characterization of three proteins that constitute two anthrax toxins. Protective antigen binds an as yet unknown cell receptor and mediates the entry of the other two components to the cytoplasm via the endosomal pathway. Edema factor, so named for its ability to induce edema, is a Ca2+ /calmodulin-dependent adenylate cyclase. Lethal factor, the dominant virulence factor associated with the toxin, proteolytically inactivates mitogen-activated protein kinase kinases, key players in signal transduction. We describe the fascinating work that has led to these discoveries End discuss their relevance to our understanding of the pathogenesis of anthrax. [References: 134]

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