Skip NavigationSkip to Content
Return Return to Search Results

Regulation and activation of p53 and its family members

  1. Author:
    Lohrum, M. A. E.
    Vousden, K. H.

  2. Author Address

    Vousden KH NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program Bldg 560,Room 22-96,W 7th St Frederick, MD 21702 USA NCI, Frederick Canc Res & Dev Ctr, ABL Basic Res Program Frederick, MD 21702 USA
    1. Year: 1999
  2. Journal: Cell Death and Differentiation
    1. 6
    2. 12
    3. Pages: 1162-1168
  4. Type of Article: Review
  1. Abstract:

    Regulation of the p53 tumor suppressor protein occurs to a large extent through control of protein stability, and the MDM2 protein has been shown to play a key role in targeting p53 for degradation. Stress signals that activate the p53 response lead to stabilization of p53 through inhibition of MDM2 mediated degradation, and it is becoming evident that a number of mechanisms exist to abrogate this activity of MDM2. Other members of the p53 protein family may also be regulated through protein stability, although MDM2 is not responsible for the degradation of p73. Nevertheless, interactions of p63 and p73 with MDM2 or p53 have been described, suggesting that each of the p53-related proteins can play some role in regulating the activity of the others. [References: 115]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.

Your Recently Viewed Publications:

Cytokine-driven cell cycling is mediated through Cdc25A
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel