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IsomiRs: Expanding the miRNA repression toolbox beyond the seed

  1. Author:
    Bofill De Ros,Xavier
    Yang,Acong
    Gu,Shuo

  2. Author Address

    NCI, RNA Mediated Gene Regulat Sect, RNA Biol Lab, Ctr Canc Res, Frederick, MD 21702 USA.
    1. Year: 2020
    2. Date: Apr
    3. Epub Date: 2019 04 03
  2. Journal: Biochimica et biophysica acta. Gene regulatory mechanisms
  3. ELSEVIER,
    1. 1863
    2. 4
  5. Type of Article: Review
  6. Article Number: 194373
  7. ISSN: 1874-9399
  1. Abstract:

    MicroRNAs (miRNAs) are a class of small non-coding RNAs that play increasingly appreciated roles in gene regulation. In animals, miRNAs silence gene expression by binding to partially complementary sequences within target mRNAs. It is well-established that miRNAs recognize canonical target sites by base-pairing in the 5'region. However, the development of biochemical methods has identified many novel, non-canonical target sites, suggesting additional modes of miRNA-target association. Here, we review the current knowledge of miRNA-target recognition and how new evidence supports or challenges existing models. We also review the process by which microRNA isoforms achieve functional diversification via modulation of target recognition.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.bbagrm.2019.03.005
  3. PMID: 30953728
  4. PMCID: PMC6776719
  5. View record in Web of Science®
  6. WOS: 000528164700004

Library Notes

  1. Fiscal Year: FY2019-2020
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