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Sleep disturbance in adults with sickle cell disease: relationships with executive and psychological functioning

  1. Author:
    Rhodes, Amanda
    Martin, Staci
    Wolters, Pamela
    Rodriguez, Yessica
    Tamula,Mary Anne
    Struemph,Kari
    Fitzhugh, Courtney
    Hsieh, Matt
    Tisdale, John

  2. Author Address

    Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 9030 Old Georgetown Road, #107, Bethesda, MD, 20892, USA., Pediatric Oncology Branch, Center for Cancer Research, National Cancer Institute, 9030 Old Georgetown Road, #107, Bethesda, MD, 20892, USA. martins@mail.nih.gov., Leidos Biomedical Research, Inc, Frederick, MD, USA., Sickle Cell Branch, National Heart, Lung, and Blood Institute, Bethesda, MD, USA.,
    1. Year: 2020
    2. Date: May 27
    3. Epub Date: 2020 05 27
  2. Journal: Annals of hematology
    1. Pages: pii: 10.1007/s00277-020-04058-7
  4. Type of Article: Article
  5. ISSN: 0939-5555
  1. Abstract:

    Sleep disturbance is common among children with sickle cell disease (SCD) and is related to neurocognitive difficulties. However, research on sleep disturbances and related variables among adults with SCD is extremely limited. The present study examined the relationship between sleep, executive functioning, and emotional functioning among 62 adults (29 females; M age 160;= 160;32 160;years, SD 160;= 160;7.79) with SCD preparing to undergo a stem cell transplant. Participants were administered a neurocognitive evaluation that included objective and subjective measures of executive functioning, and they completed PROMIS self-report measures of anxiety, depression, and pain intensity. Results showed that about 17% of participants endorsed clinically significant sleep disruptions, while 16.1% and 8% endorsed clinically significant symptoms of anxiety and depression, respectively. Sleep disturbance in these adults was not significantly correlated with objective or subjective measures of executive functioning. Moreover, anxiety, but not depression, was a significant mediator between self-reported sleep difficulties and both objective and subjective measures of executive functioning while controlling for pain intensity. Future research on sleep interventions will be essential for ameliorating the effects of sleep disturbance on executive functioning and anxiety among adults with SCD.

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External Sources

  1. View Full Text
  2. DOI: 10.1007/s00277-020-04058-7
  3. PMID: 32458066
  4. View record in Web of Science®
  5. WOS: 000553513000001
  6. PII : 10.1007/s00277-020-04058-7

Library Notes

  1. Fiscal Year: FY2019-2020
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