Skip NavigationSkip to Content
Return Return to Search Results

Characteristics of HIV-1 env genes from Chinese chronically infected donors with highly broad cross-neutralizing activity

  1. Author:
    Sha, Sun Sha
    Dai, Zhang
    Wei, Qi Zhong
    Hu,Xintao
    Yuan, Hu Yuan
    Li, Ren
    Ying, Liu
    Li Ying, Ma
    Ming, Shao Yi
    Xue, Hong Kun

  2. Author Address

    State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: sha837982611@hotmail.com., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China; The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou, 450052, Henan, China. Electronic address: zhangdai1999@126.com., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: qizhongwei1810@163.com., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute, Frederick, MD, United States. Electronic address: xth38302@126.com., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: yyh5223@163.com., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: L_REN@hotmail.com., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: liuy@163.com., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: mal@chinaaids.cn., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: yshao08@gmail.com., State Key Laboratory of Infectious Disease Prevention and Control, National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, 102206, China. Electronic address: hongkx@chinaaids.cn.,
    1. Year: 2020
    2. Date: DEC
    3. Epub Date: 2020 09 28
  2. Journal: Virology
    1. 551
    2. Pages: 16-25
  4. Type of Article: Article
  5. ISSN: 0042-6822
  1. Abstract:

    Knowledge about the special characteristics of HIV-1 envelope (env) glycoproteins in rare individuals developing >90% neutralization breadth in Chinese subtype B' slow progressors may provide insights for vaccine design against local viruses. We performed a cross-sectional analysis on 7 samples. We tested the neutralization breadth and geometric mean ID50 titers (GMTs) of these samples, and divided them into hBCN+ and hBCN- group according to whether their neutralization breadth >90%. We obtained env sequences in these samples through single genome amplification (SGA) assay. By comparing with hBCN-, subtype B chronically infected group (B-SP), and Chinese subtype B group (B-Database), we analyzed the characteristics of the env sequences of hBCN+ group. Longer V1 and V4 regions with more glycosylation sites were found in hBCN+ samples compared to hBCN- samples. Further analysis compared to B-SP and B-Database showed that hBCN+ group exhibited unique extra-long V1 region containing higher proportion of N-glycan sites and additional cysteines. Copyright © 2020. Published by Elsevier Inc.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.virol.2020.08.012
  3. PMID: 33010671
  4. View record in Web of Science®
  5. WOS: 000591845000003
  6. PII : S0042-6822(20)30173-2

Library Notes

  1. Fiscal Year: FY2020-2021
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel