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swi1 and swi3 perform imprinting, pausing, and termination of DNA replication in S-pombe

  1. Author:
    Dalgaard, J. Z.
    Klar, A. J. S.

  2. Author Address

    NCI, DHHS, Div Basic Sci, Gene Regulat & Chromosome Biol Lab, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA. NCI, DHHS, Div Basic Sci, Gene Regulat & Chromosome Biol Lab, Frederick Canc Res & Dev Ctr, Frederick, MD 21702 USA.
    1. Year: 2000
  2. Journal: Cell
    1. 102
    2. 6
    3. Pages: 745-751
  4. Type of Article: Article
  1. Abstract:

    The developmental program of cell-type switching of S. pombe requires a strand-specific imprinting event at the mating-type locus (mat1). Imprinting occurs only when mat1 is replicated in a specific direction and requires several trans-acting factors. This work shows (1) that the factors swi1p and swi3p act by pausing the replication fork at the imprinting site; and (2) that swi1p and swi3p are involved in termination at the mat1- proximal polar-terminator of replication (RTS1). A genetic screen to identify termination factors identified an allele that separated pausing/imprinting and termination functions of swi1p. These results suggest that swi1p and swi3p promote imprinting in novel ways both by pausing replication at mat1 and by terminating replication at RTS1.

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