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The Genes Encoding the Peripheral Cannabinoid Receptor and Alpha-L-Fucosidase Are Located Near a Newly Identified Common Virus Integration Site, Evi11

  1. Author:
    Valk, P. J. M.
    Hol, S.
    Vankan, Y.
    Ihle, J. N.
    Askew, D.
    Jenkins, N. A.
    Gilbert, D. J.
    Copeland, N. G.
    Deboth, N. J.
    Lowenberg, B.
    Delwel, R.

  2. Author Address

    Delwel R ERASMUS UNIV ROTTERDAM INST HEMATOL POB 1738 NL-3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM INST HEMATOL NL-3000 DR ROTTERDAM NETHERLANDS ERASMUS UNIV ROTTERDAM DEPT PATHOL NL-3000 DR ROTTERDAM NETHERLANDS ST JUDE CHILDRENS HOSP DEPT BIOCHEM MEMPHIS, TN 38105 USA UNIV CINCINNATI DEPT PATHOL & LAB MED CINCINNATI, OH 45267 USA NCI MAMMALIAN GENET LAB ABL BASIC RES PROGRAM FREDERICK CANC RES & DEV CTR FREDERICK, MD 21702 USA
    1. Year: 1997
  2. Journal: Journal of Virology
    1. 71
    2. 9
    3. Pages: 6796-6804
  4. Type of Article: Article
  1. Abstract:

    A new common region of virus integration, Evi11, has been identified in two retrovirally induced murine myeloid leukemia cell lines, NFS107 and NFS78, By interspecific backcross analysis, it was shown that Evi11 is located at the distal end of mouse chromosome 4, in a region that shows: homolog with human 1p36, The genes encoding the peripheral cannabinoid receptor (Cnr2) and alpha-L-fucosidase (Fuca1) were identified near the integration site by using a novel exon trapping system, Cnr2 is suggested to be the target gene for viral interference in Evi11, since proviruses are integrated in the first intron of Cnr2 and retroviral integrations alter mRNA expression of Cnr2 in NFS107 and NFS78, In addition, proviral integrations were demonstrated within the 3' untranslated region of Cnr 2 in five independent newly derived CasBrM-MuLV (mouse murine leukemia virus) tumors, CSL13, CSL14 CSL16, CSL27, and CSL97. The Cnr2 gene encodes a seven-transmembrane G-protein-coupled receptor which is normally expressed in hematopoietic tissues, Our data suggest that the peripheral cannabinoid receptor gene might he involved in leukemogenesis as a result of aberrant expression of Cnr2 due to retroviral integration in Evi11. [References: 55]

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