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Longitudinal changes in CD4(+) T cell antigen receptor diversity and naive/memory cell phenotype during 9 to 26 months of antiretroviral therapy of HIV-infected patients

  1. Author:
    Gea-Banacloche, J. C.
    Martino, L.
    Mican, J. M.
    Hallahan, C. W.
    Baseler, M.
    Stevens, R.
    Lambert, L.
    Polis, M.
    Lane, H. C.
    Connors, M.

  2. Author Address

    NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. NIAID, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA. SAIC Frederick Canc Res & Dev Ctr, Frederick, MD USA.
    1. Year: 2000
  2. Journal: Aids Research and Human Retroviruses
    1. 16
    2. 17
    3. Pages: 1877-1886
  4. Type of Article: Article
  1. Abstract:

    Although skewing of the CD4(+) TCR repertoire in advanced HIV infection is well documented, increases in polyclonality during antiretroviral therapy have been less consistently observed. Ten patients, each with documented abnormalities within the CD4(+) TCR repertoire, were studied by CDR3 spectratyping, semiquantitative PCR, and SSCP during 9-26 months of therapy. Naive and memory cell phenotypes were analyzed by flow cytometry. Six of 10 patients showed increased polyclonality of their TCR repertoires, 1 showed no change, and 3 showed increased TCR skewing, despite suppressed viral replication. Overall, there was no significant change in the percentage of abnormal BV subfamilies (from a mean of 25.5 to 17.1%) or the percentage of naive CD4(+) T cells (from a mean of 18 to 25%). Further, progression of TCR repertoire disruptions was observed in some patients even with suppression of plasma viral RNA below 500 copies/ml. Although a spectrum of changes may be seen within the CD4(+) TCR repertoire in the setting of antiretroviral therapy, increases in polyclonality are observed in some patients.

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