Skip NavigationSkip to Content
Return Return to Search Results

BP1, a new homeobox gene, is frequently expressed in acute leukemias

  1. Author:
    Haga, S. B.
    Fu, S.
    Karp, J. E.
    Ross, D. D.
    Williams, D. M.
    Hankins, W. D.
    Behm, F.
    Ruscetti, F. W.
    Chang, M.
    Smith, B. D.
    Becton, D.
    Raimondi, S. C.
    Berg, P. E.

  2. Author Address

    George Washington Univ, Med Ctr, Dept Biochem & Mol Biol, Ross Bldg, Room 533, 2300 Eye St NW, Washington, DC 20037 USA. George Washington Univ, Med Ctr, Dept Biochem & Mol Biol, Washington, DC 20037 USA. Univ Maryland, Sch Med, Div Human Genet, Baltimore, MD 21201 USA. Univ Maryland, Sch Med, Greenebaum Canc Ctr, Baltimore, MD 21201 USA. Dept Vet Affairs, Baltimore Vet Med Ctr, Baltimore, MD USA. Johns Hopkins Univ, Dept Med, Baltimore, MD USA. ProED Inc, Bethesda, MD USA. St Jude Childrens Res Hosp, Dept Pathol & Lab Med, Memphis, TN 38105 USA. NCI, Frederick Canc Res & Dev Ctr, Lab Leukocyte Biol, Frederick, MD USA. Univ Florida, Stat Off, Gainesville, FL USA. Johns Hopkins Univ, Johns Hopkins Oncol Ctr, Baltimore, MD USA. Univ Arkansas Med Sci, Dept Pediat, Little Rock, AR 72205 USA.
    1. Year: 2000
  2. Journal: Leukemia
    1. 14
    2. 11
    3. Pages: 1867-1875
  4. Type of Article: Article
  1. Abstract:

    Aberrant expression of homeobox genes has been described in primary leukemia blasts. We recently cloned a new cDNA, BP1, which is a member of the homeobox gene family. BP1 expression was investigated in bone marrow samples from acute myeloid leukemia (AML), acute T cell lymphocytic leukemia (ALL) and pre-B cell ALL. Expression levels of two apparent isoforms of BP1, DLX7 and DLX4, were measured in the same samples. They are weakly if at all detectable in normal bone marrow, PHA- stimulated T cells or B cells. BP1 RNA was highly expressed in 63% of AML cases, including 81% of the pediatric and 47% of the adult cases, and in 32% of T-ALL cases, but was not found in any of the pre-B ALL cases. Coexpression of BP1, DLX7 and DLX4 occurred in a significant number of leukemias. Our data, including co-expression of BP1 with c-myb and GATA-1, markers of early progenitors, suggest that BP1 expression occurs in primitive cells in AML. Analysis of CD34(+) and CD34(-) normal bone marrow cells revealed BP1 is expressed in CD34- cells and virtually extinguished in CD34(+) cells. Ectopic expression of BP1 in the leukemia cell line K562 increased clonogenicity, consistent with a role for BP1 in leukemogenesis. The presence of BP1 RNA in leukemic blasts may therefore be a molecular marker for primitive cells and/or may indicate that BP1 is an important upstream factor in an oncogenic pathway.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel