Skip NavigationSkip to Content
Return Return to Search Results

Malaria Is Associated With Kaposi Sarcoma-Associated Herpesvirus Seroconversion in a Cohort of Western Kenyan Children

  1. Author:
    Sabourin, Katherine R
    Daud, Ibrahim
    Ogolla, Sidney
    Labo,Nazzarena
    Miley,Wendell
    Lamb, Molly
    Newton, Robert
    Whitby,Denise
    Rochford, Rosemary

  2. Author Address

    Department of Epidemiology, Colorado School of Public Health, Denver, USA., Department of Immunology and Microbiology, University of Colorado, Denver, USA., Centre for Global Health Research, Kenya Medical Research Institute, Kisumu, Kenya., United States Army Medical Research Laboratories Directorate - Africa/Kenya, Kericho, Kenya., Frederick National Laboratory for Cancer Research, Leidos Biomedical Research, Frederick, Maryland, USA., department of Health Sciences, University of York, York, UK.,
    1. Year: 2021
    2. Date: Jul 15
    3. Epub Date: 2020 11 29
  2. Journal: The Journal of infectious diseases
    1. 224
    2. 2
    3. Pages: 303-311
  4. Type of Article: Article
  5. ISSN: 0022-1899
  1. Abstract:

    Background: We aimed to determine whether Plasmodium falciparum (Pf) infection affects age of Kaposi sarcoma-associated herpesvirus (KSHV) seroconversion in Kenyan children. Methods: Kenyan children (n=144) enrolled at age one month, from two sites with different levels of malaria transmission (stable/high malaria vs. unstable/low malaria transmission) were followed through 24 months. Plasma was tested for KSHV antibodies using enzyme-linked immunosorbent assay (ELISA) (K8.1 and LANA) and a multiplex bead-based assay (K8.1, K10.5, ORF38, ORF50, and LANA) and whole blood tested for Pf DNA using quantitative-PCR. Cox proportional hazards models were used to assess associations between Pf DNA detection, malaria annualized rate (Pf detections/person-years), and enrollment site (malaria-high vs malaria-low) with time to KSHV seroconversion. Results: KSHV seroprevalence was 63% by 2 years of age when assessed by multiplex assay. Children with Pf were at increased hazards of earlier KSHV seroconversion and among children with malaria, the hazard of becoming KSHV seropositive increased significantly with increasing malaria annualized rate. Children from the malaria-high transmission region had no significant difference in hazards of KSHV seroconversion at 12 months but were more likely to become KSHV seropositive by 24 months of age. Discussion: Malaria exposure increases the risk for KSHV seroconversion early in life. Keywords: HHV-8; KSHV; Kaposi sarcoma-associated herpesvirus; Malaria; Sub-Saharan Africa. © The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1093/infdis/jiaa740
  3. PMID: 33249494
  4. View record in Web of Science®
  5. WOS: 000693671600014
  6. PII : 6010567

Library Notes

  1. Fiscal Year: FY2020-2021
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel