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Contributions of the international plant science community to the fight against human infectious diseases - part 1: epidemic and pandemic diseases

  1. Author:
    Lobato Gomez, Maria
    Huang, Xin
    Alvarez, Derry
    He, Wenshu
    Baysal, Can
    Zhu, Changfu
    Armario-Najera, Victoria
    Blanco Perera, Amaya
    Cerda Bennasser, Pedro
    Saba-Mayoral, Andera
    Sobrino-Mengual, Guillermo
    Vargheese, Ashwin
    Abranches, Rita
    Abreu, Isabel Alexandra
    Balamurugan, Shanmugaraj
    Bock, Ralph
    Buyel, Johannes. F.
    da Cunha, Nicolau B.
    Daniell, Henry
    Faller, Roland
    Folgado, Andre
    Gowtham, Iyappan
    Hakkinen, Suvi T.
    Kumar, Shashi
    Ramalingam, Sathish Kumar
    Lacorte, Cristiano
    Lomonossoff, George P.
    Luis, Ines M.
    Ma, Julian K. -C.
    McDonald, Karen. A.
    Murad, Andre
    Nandi, Somen
    O'Keefe,Barry
    Oksman-Caldentey, Kirsi-Marja
    Parthiban, Subramanian
    Paul, Mathew J.
    Ponndorf, Daniel
    Rech, Elibio
    Rodrigues, Julio C. M.
    Ruf, Stephanie
    Schillberg, Stefan
    Schwestka, Jennifer
    Shah, Priya S.
    Singh, Rahul
    Stoger, Eva
    Twyman, Richard M.
    Varghese, Inchakalody P.
    Vianna, Giovanni R.
    Webster, Gina
    Wilbers, Ruud H. P.
    Capell, Teresa
    Christou, Paul

  2. Author Address

    Univ Lleida, Agrotecnio CERCA Ctr, Dept Crop & Forest Sci, Lleida, Spain.Univ Nova Lisboa, Inst Tecnol Quim & Biol Antonio Xavier, Oeiras, Portugal.Bharathiar Univ, Dept Biotechnol, Plant Genet Engn Lab, Coimbatore, Tamil Nadu, India.Max Planck Inst Mol Plant Physiol, Potsdam, Germany.Fraunhofer Inst Mol Biol & Appl Ecol IME, Aachen, Germany.Rhein Westfal TH Aachen, Inst Mol Biotechnol, Aachen, Germany.Univ Catolica Brasilia, Ctr Analise Proteom & Bioquim Brasila, Brasilia, DF, Brazil.Univ Penn, Sch Dent Med, Philadelphia, PA 19104 USA.Univ Calif Davis, Dept Chem Engn, Davis, CA USA.VTT Tech Res Ctr Finland Ltd, Ind Biotechnol & Food Solut, Espoo, Finland.Int Ctr Genet Engn & Biotechnol, New Delhi, India.Brazilian Agr Res Corp, Embrapa Genet Resources & Biotechnol, Parque Estacao Biol, Brasilia, DF, Brazil.Natl Inst Sci & Technol Synthet Biol, Parque Estacao Biol, Brasilia, DF, Brazil.John Innes Ctr, Dept Biol Chem, Norwich, Norfolk, England.St Georges Univ London, Inst Infect & Immun, London, England.Univ Calif Davis, Global HealthShare Initiat, Davis, CA USA.NCI, Ctr Canc Res, Mol Targets Program, Frederick, MD USA.NIH, NCI, Div Canc Treatment & Diag, Nat Prod Branch,Dev Therapeut Program, Frederick, MD USA.Justus Liebig Univ Giessen, Inst Phytopathol, Giessen, Germany.Univ Nat Resources & Life Sci, Inst Plant Biotechnol & Cell Biol, Vienna, Austria.Univ Calif Davis, Dept Microbiol & Mol Genet, Davis, CA 95616 USA.TRM Ltd, Scarborough, England.Wageningen Univ & Res, Plant Sci Grp, Lab Nematol, Wageningen, Netherlands.Catalan Inst Res & Adv Studies, ICREA, Barcelona, Spain.
    1. Year: 2021
    2. Date: Jun 28
    3. Epub Date: 2021 06 28
  2. Journal: Plant biotechnology journal
  3. WILEY,
  5. Type of Article: Review
  6. ISSN: 1467-7644
  1. Abstract:

    Infectious diseases, also known as transmissible or communicable diseases, are caused by pathogens or parasites that spread in communities by direct contact with infected individuals or contaminated materials, through droplets and aerosols, or via vectors such as insects. Such diseases cause similar to 17% of all human deaths and their management and control places an immense burden on healthcare systems worldwide. Traditional approaches for the prevention and control of infectious diseases include vaccination programmes, hygiene measures and drugs that suppress the pathogen, treat the disease symptoms or attenuate aggressive reactions of the host immune system. The provision of vaccines and biologic drugs such as antibodies is hampered by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, particularly in developing countries where infectious diseases are prevalent and poorly controlled. Molecular farming, which uses plants for protein expression, is a promising strategy to address the drawbacks of current manufacturing platforms. In this review article, we consider the potential of molecular farming to address healthcare demands for the most prevalent and important epidemic and pandemic diseases, focussing on recent outbreaks of high-mortality coronavirus infections and diseases that disproportionately affect the developing world.

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  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1111/pbi.13657
  3. PMID: 34182608
  4. View record in Web of Science®
  5. WOS: 000674418900001

Library Notes

  1. Fiscal Year: FY2020-2021
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