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Type 2 immunity induced by bladder extracellular matrix enhances corneal wound healing

  1. Author:
    Wang, Xiaokun
    Chung, Liam
    Hooks, Joshua
    Maestas, David R. Jr Jr
    Lebid, Andriana
    Andorko, James
    Huleihel, Luai
    Chin, Alexander F.
    Wolf,Matthew
    Remlinger, Nathaniel T.
    Stepp, Mary Ann
    Housseau, Franck
    Elisseeff, Jennifer H.

  2. Author Address

    Johns Hopkins Sch Med, Translat Tissue Engn Ctr, Baltimore, MD 21231 USA.Johns Hopkins Univ, Sch Med, Bloomberg Kimmel Inst Canc Immunotherapy, Baltimore, MD 21231 USA.Johns Hopkins Univ, Sch Med, Sidney Kimmel Comprehens Canc Ctr, Baltimore, MD 21231 USA.ACell Inc, Columbia, MD 21046 USA.Univ Pittsburgh, McGowan Inst Regenerat Med, Pittsburgh, PA 15219 USA.Johns Hopkins Univ, Dept Biomed Engn, Baltimore, MD 21218 USA.NCI, Lab Canc Immunometab, Ctr Canc Res, Frederick, MD 21702 USA.George Washington Univ, Sch Med & Hlth Sci, Dept Anat & Cell Biol, Washington, DC 20037 USA.George Washington Univ, Sch Med & Hlth Sci, Dept Ophthalmol, Washington, DC 20037 USA.
    1. Year: 2021
    2. Date: Apr
  2. Journal: SCIENCE ADVANCES
  3. AMER ASSOC ADVANCEMENT SCIENCE,
    1. 7
    2. 16
  5. Type of Article: Article
  6. Article Number: eabe2635
  7. ISSN: 2375-2548
  1. Abstract:

    The avascular nature of cornea tissue limits its regenerative potential, which may lead to incomplete healing and formation of scars when damaged. Here, we applied micro- and ultrafine porcine urinary bladder matrix (UBM) particulate to promote type 2 immune responses in cornea wounds. Results demonstrated that UBM particulate substantially reduced corneal haze formation as compared to the saline-treated group. Flow cytometry and gene expression analysis showed that UBM particulate suppressed the differentiation of corneal stromal cells into alpha-smooth muscle actin-positive (alpha SMA(+)) myofibroblasts. UBM treatments up-regulated interleukin-4 (IL-4) produced primarily by eosinophils in the wounded corneas and CD4(+) T cells in draining lymph nodes, suggesting a cross-talk between local and peripheral immunity. Gata1(-/-) mice lacking eosinophils did not respond to UBM treatment and had impaired wound healing. In summary, stimulating type 2 immune responses in the wounded cornea can promote proregenerative environments that lead to improved wound healing for vision restoration.

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External Sources

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  2. DOI: 10.1126/sciadv.abe2635
  3. View record in Web of Science®
  4. WOS: 000677572500002

Library Notes

  1. Fiscal Year: FY2020-2021
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