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Contributions of the international plant science community to the fight against infectious diseases in humans-part 2: Affordable drugs in edible plants for endemic and re-emerging diseases

  1. Author:
    He, Wenshu
    Baysal, Can
    Lobato Gomez, Maria
    Huang, Xin
    Alvarez, Derry
    Zhu, Changfu
    Armario-Najera, Victoria
    Blanco Perera, Aamaya
    Cerda Bennaser, Pedro
    Saba-Mayoral, Andrea
    Sobrino-Mengual, Guillermo
    Vargheese, Ashwin
    Abranches, Rita
    Alexandra Abreu, Isabel
    Balamurugan, Shanmugaraj
    Bock, Ralph
    Buyel, Johannes F.
    da Cunha, Nicolau B.
    Daniell, Henry
    Faller, Roland
    Folgado, Andre
    Gowtham, Iyappan
    Hakkinen, Suvi T.
    Kumar, Shashi
    Sathish Kumar, Ramalingam
    Lacorte, Cristiano
    Lomonossoff, George P.
    Luis, Ines M.
    K.-C. Ma, Julian
    McDonald, Karen A.
    Murad, Andre
    Nandi, Somen
    O'Keefe,Barry
    Parthiban, Subramanian
    Paul, Mathew J.
    Ponndorf, Daniel
    Rech, Elibio
    Rodrigues, Julio C. M.
    Ruf, Stephanie
    Schillberg, Stefan
    Schwestka, Jennifer
    Shah, Priya S.
    Singh, Rahul
    Stoger, Eva
    Twyman, Richard M.
    Varghese, Inchakalody P.
    Vianna, Giovanni R.
    Webster, Gina
    Wilbers, Ruud H. P.
    Christou, Paul
    Oksman-Caldentey, Kirsi-Marja
    Capell, Teresa

  2. Author Address

    Univ Lleida Agrotecnio CERCA Ctr, Dept Crop & Forest Sci, Lleida, Spain.Univ Nova Lisboa, Inst Tecnologia Quimica Biologica Antonio Xavier, Oeiras, Portugal.Bharathiar Univ, Dept Biotechnol, Plant Genet Engn Lab, Coimbatore, Tamil Nadu, India.Max Planck Inst Mol Plant Physiol, Potsdam Golm, Germany.Fraunhofer Inst Mol Biol & Appl Ecol IME, Aachen, Germany.Rhein Westfal TH Aachen, Inst Mol Biotechnol, Aachen, Germany.Univ Catolica Bras ilia, Centro alise Proteomicas Bioquimicas Brasilia, Brasilia, DF, Brazil.Univ Penn, Sch Dent Med, Philadelphia, PA USA.Univ California, Dept Chem Engn, Davis, CA USA.VTT Tech Res Ctr Finland Ltd, Ind Biotechnol & Food Solut, Espoo, Finland.Int Ctr Genet Engn & Biotechnol, New Delhi, India.Embrapa Genet Resources & Biotechnol & Natl Inst, Brazilian Agr Res Corp, Parque Estacao Biologica, Brasilia, DF, Brazil.Dept Biol Chem, John Innes Ctr, Res Pk, Norwich, Norfolk, England.St Georges Univ London, Inst Infect & Immun, London, England.Univ California, Global HealthShare Initiat, Davis, CA USA.NIH, Natl Canc Inst, Div Canc Treatment & Diag, Ctr Canc Res,Nat Prod Branch,Dev Therapeutics, Frederick, MD USA.Justus Liebig Univ Giessen, Inst Phytopathol, Giessen, Germany.Univ Nat Resources & Life Sci, Inst Plant Biotechnol & Cell Biol, Vienna, Austria.Univ California, Dept Microbiol & Mol Genet, Davis, CA USA.TRM Ltd, Scarborough, England.Wageningen Univ & Res, Plant Sci Grp, Nematol Lab, Wageningen, Netherlands.Catalan Inst Res & Adv Studies, ICREA, Barcelona, Spain.
    1. Year: 2021
    2. Date: Jul 19
    3. Epub Date: 2021 06 28
  2. Journal: Plant biotechnology journal
  3. WILEY,
  5. Type of Article: Review
  6. ISSN: 1467-7644
  1. Abstract:

    The fight against infectious diseases often focuses on epidemics and pandemics, which demand urgent resources and command attention from the health authorities and media. However, the vast majority of deaths caused by infectious diseases occur in endemic zones, particularly in developing countries, placing a disproportionate burden on underfunded health systems and often requiring international interventions. The provision of vaccines and other biologics is hampered not only by the high cost and limited scalability of traditional manufacturing platforms based on microbial and animal cells, but also by challenges caused by distribution and storage, particularly in regions without a complete cold chain. In this review article, we consider the potential of molecular farming to address the challenges of endemic and re-emerging diseases, focusing on edible plants for the development of oral drugs. Key recent developments in this field include successful clinical trials based on orally delivered dried leaves of Artemisia annua against malarial parasite strains resistant to artemisinin combination therapy, the ability to produce clinical-grade protein drugs in leaves to treat infectious diseases and the long-term storage of protein drugs in dried leaves at ambient temperatures. Recent FDA approval of the first orally delivered protein drug encapsulated in plant cells to treat peanut allergy has opened the door for the development of affordable oral drugs that can be manufactured and distributed in remote areas without cold storage infrastructure and that eliminate the need for expensive purification steps and sterile delivery by injection.

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External Sources

  1. View Full Text
  2. DOI: 10.1111/pbi.13658
  3. PMID: 34181810
  4. View record in Web of Science®
  5. WOS: 000674418700001

Library Notes

  1. Fiscal Year: FY2020-2021
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